MetaCyc Pathway: <i>O</i>-antigen building blocks biosynthesis (<i>E. coli</i>) in Paraburkholderia sabiae LMG 24235

MetaCyc Pathway: O-antigen building blocks biosynthesis (E. coli) in Paraburkholderia sabiae LMG 24235

UDP-galactopyranose mutase:
UDP-α-D-galactose→UDP-α-D-galactofuranose (EC 5.4.99.9)

No genes

Glucose-6-phosphate isomerase:
α-D-glucose 6-phosphate→β-D-fructofuranose 6-phosphate (EC 5.3.1.9)

Phosphoglucomutase (in reverse):
D-glucopyranose 6-phosphate→α-D-glucopyranose 1-phosphate (EC 5.4.2.2)

Glucose-1-phosphate thymidylyltransferase:
α-D-glucopyranose 1-phosphate + H⁺ + dTTP→dTDP-α-D-glucose + diphosphate (EC 2.7.7.24)

Glutamine--fructose-6-phosphate transaminase (isomerizing):
β-D-fructofuranose 6-phosphate + L-glutamine→D-glucosamine 6-phosphate + L-glutamate (EC 2.6.1.16)

Phosphoglucosamine mutase:
D-glucosamine 6-phosphate→α-D-glucosamine 1-phosphate (EC 5.4.2.10)

dTDP-glucose 4,6-dehydratase:
dTDP-α-D-glucose→dTDP-4-dehydro-6-deoxy-α-D-glucopyranose + H₂O (EC 4.2.1.46)

Glucosamine-1-phosphate N-acetyltransferase:
α-D-glucosamine 1-phosphate + acetyl-CoA→N-acetyl-α-D-glucosamine 1-phosphate + coenzyme A + H⁺ (EC 2.3.1.157)

dTDP-4-dehydrorhamnose 3,5-epimerase:
dTDP-4-dehydro-6-deoxy-α-D-glucopyranose→dTDP-4-dehydro-β-L-rhamnose (EC 5.1.3.13)

dTDP-4-dehydrorhamnose reductase (in reverse):
dTDP-4-dehydro-β-L-rhamnose + NADPH + H⁺→dTDP-β-L-rhamnose + NADP⁺ (EC 1.1.1.133)

UDP-N-acetylglucosamine diphosphorylase:
N-acetyl-α-D-glucosamine 1-phosphate + H⁺ + UTP→UDP-N-acetyl-α-D-glucosamine + diphosphate (EC 2.7.7.23)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information