MetaCyc Pathway: trans-4-hydroxy-L-proline degradation I in Paraburkholderia sabiae LMG 24235

Add experiment(s):


trans-4-hydroxy-L-proline[in] + an electron-transfer quinone→(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate[in] + an electron-transfer quinol + H+[in] (EC 1.5.5.3)
No genes
(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + H+ + H2O→L-4-hydroxyglutamate semialdehyde (spontaneous)
No genes
L-4-hydroxyglutamate semialdehyde + NAD+ + H2O→erythro-4-hydroxy-L-glutamate + NADH + 2 H+
QEN71_RS36450
4-hydroxyglutamate transaminase:
erythro-4-hydroxy-L-glutamate + 2-oxoglutarate→(4R)-4-hydroxy-2-oxoglutarate + L-glutamate (EC 2.6.1.23)
QEN71_RS00075
QEN71_RS02890
QEN71_RS03175
QEN71_RS03275
QEN71_RS06560
QEN71_RS08880
QEN71_RS10500
QEN71_RS12205
QEN71_RS12215
QEN71_RS13030
QEN71_RS17025
QEN71_RS18160
QEN71_RS18375
QEN71_RS20720
QEN71_RS21505
QEN71_RS22410
QEN71_RS23125
QEN71_RS23470
QEN71_RS24010
QEN71_RS24645
QEN71_RS30710
QEN71_RS31640
QEN71_RS32300
QEN71_RS36905
QEN71_RS38860
QEN71_RS38900
QEN71_RS38970
4-hydroxy-2-oxoglutarate aldolase:
(4R)-4-hydroxy-2-oxoglutarate→glyoxylate + pyruvate (EC 4.1.3.16)
QEN71_RS26915

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information