MetaCyc Pathway: L-valine degradation I in Hydrogenophaga sp. GW460-11-11-14-LB1

Add experiment(s):


Branched-chain-amino-acid transaminase:
L-valine + 2-oxoglutarate→3-methyl-2-oxobutanoate + L-glutamate (EC 2.6.1.42)
GFF1835
2-oxoisovalerate dehydrogenase (acylating):
3-methyl-2-oxobutanoate + coenzyme A + NAD+→isobutanoyl-CoA + CO2 + NADH (EC 1.2.1.25)
No genes
isobutanoyl-CoA + an oxidized electron-transfer flavoprotein + H+→methylacrylyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.5)
No genes
methylacrylyl-CoA + H2O→(S)-3-hydroxy-isobutanoyl-CoA (EC 4.2.1.150)
GFF1003
GFF1566
GFF2070
GFF2072
GFF2109
GFF2111
GFF238
GFF2746
GFF2842
GFF2897
GFF2983
GFF3034
GFF3054
GFF3395
GFF3472
GFF3784
GFF4130
GFF414
GFF418
GFF4348
GFF435
GFF436
GFF4405
GFF4416
GFF4496
GFF4592
GFF4819
GFF482
GFF513
GFF5528
GFF5614
GFF5622
GFF5663
GFF5664
GFF5669
GFF5848
GFF5853
GFF5854
GFF619
GFF620
GFF726
GFF882
GFF915
GFF918
GFF931
GFF969
GFF979
3-hydroxyisobutyryl-CoA hydrolase:
(S)-3-hydroxy-isobutanoyl-CoA + H2O→(S)-3-hydroxy-isobutanoate + coenzyme A + H+ (EC 3.1.2.4)
No genes
3-hydroxyisobutyrate dehydrogenase:
(S)-3-hydroxy-isobutanoate + NAD+→(S)-methylmalonate-semialdehyde + NADH + H+ (EC 1.1.1.31)
GFF2109
GFF414
GFF4497
GFF4592
GFF4826
GFF5620
GFF5662
GFF875
(S)-3-amino-2-methylpropionate transaminase (in reverse):
(S)-methylmalonate-semialdehyde + L-glutamate→(S)-3-amino-2-methylpropanoate + 2-oxoglutarate (EC 2.6.1.22)
No genes
Methylmalonate-semialdehyde dehydrogenase (acylating):
(S)-methylmalonate-semialdehyde + coenzyme A + NAD+ + H2O→propanoyl-CoA + hydrogen carbonate + NADH + H+ (EC 1.2.1.27)
GFF1895

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information