MetaCyc Pathway: mycolate biosynthesis in Hydrogenophaga sp. GW460-11-11-14-LB1

Add experiment(s):


lauroyl-CoA + a malonyl-[acp] + H+→a 3-oxotetradecanoyl-[acp] + CO2 + coenzyme A (EC 2.3.1.301)
No genes
Fatty-acyl-CoA synthase:
a palmitoyl-[acp domain within a fatty acid synthase] + malonyl-CoA + H+→a 3-oxooctadecanoyl-[acp domain within a fatty acid synthase] + CO2 + coenzyme A
(EC 2.3.1.86)
No genes
Fatty-acyl-CoA synthase (in reverse):
a 3-oxooctadecanoyl-[acp domain within a fatty acid synthase] + NADPH + H+→a (3R)-3-hydroxyoctadecanoyl-[acp domain within a fatty acid synthase] + NADP+
(EC 2.3.1.86)
No genes
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxotetradecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxytetradecanoyl-[acp] + NADP+
(EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
Fatty-acyl-CoA synthase:
a (3R)-3-hydroxyoctadecanoyl-[acp domain within a fatty acid synthase]→a (2E)-octadec-2-enoyl-[acp domain within a fatty acid synthase] + H2O
(EC 2.3.1.86)
No genes
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxytetradecanoyl-[acp]→a (2E)-tetradec-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
GFF4904
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-tetradec-2-enoyl-[acp] + NADH + H+→a myristoyl-[acp] + NAD+
(EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
Fatty-acyl-CoA synthase (in reverse):
a (2E)-octadec-2-enoyl-[acp domain within a fatty acid synthase] + NADPH + H+→a stearoyl-[acp domain within a fatty acid synthase] + NADP+
(EC 2.3.1.86)
No genes
Fatty-acyl-CoA synthase:
a stearoyl-[acp domain within a fatty acid synthase] + malonyl-CoA + H+→a 3-oxoicosanoyl-[acp domain within a fatty acid synthase] + CO2 + coenzyme A
(EC 2.3.1.86)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a myristoyl-[acp] + a malonyl-[acp] + H+→a 3-oxohexadecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
GFF2998
GFF3009
GFF3337
GFF4995
Fatty-acyl-CoA synthase (in reverse):
a 3-oxoicosanoyl-[acp domain within a fatty acid synthase] + NADPH + H+→a (3R)-3-hydroxyicosanoyl-[acp domain within a fatty acid synthase] + NADP+
(EC 2.3.1.86)
No genes
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxohexadecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyhexadecanoyl-[acp] + NADP+
(EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyhexadecanoyl-[acp]→a (2E)-hexadec-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
GFF4904
Fatty-acyl-CoA synthase:
a (3R)-3-hydroxyicosanoyl-[acp domain within a fatty acid synthase]→a (2E)-icos-2-enoyl-[acp domain within a fatty acid synthase] + H2O
(EC 2.3.1.86)
No genes
Fatty-acyl-CoA synthase (in reverse):
a (2E)-icos-2-enoyl-[acp domain within a fatty acid synthase] + NADPH + H+→an icosanoyl-[acp domain within a fatty acid synthase] + NADP+
(EC 2.3.1.86)
No genes
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-hexadec-2-enoyl-[acp] + NADH + H+→a palmitoyl-[acp] + NAD+
(EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
Fatty-acyl-CoA synthase:
an icosanoyl-[acp domain within a fatty acid synthase] + malonyl-CoA + H+→a 3-oxodocosanoyl-[acp domain within a fatty acid synthase] + CO2 + coenzyme A
(EC 2.3.1.86)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase I:
a palmitoyl-[acp] + a malonyl-[acp] + H+→a 3-oxooctadecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.41)
GFF3009
GFF4995
Fatty-acyl-CoA synthase (in reverse):
a 3-oxodocosanoyl-[acp domain within a fatty acid synthase] + NADPH + H+→a (3R)-3-hydroxydocosanoyl-[acp domain within a fatty acid synthase] + NADP+
(EC 2.3.1.86)
No genes
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxooctadecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyoctadecanoyl-[acp] + NADP+
(EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
Fatty-acyl-CoA synthase:
a (3R)-3-hydroxydocosanoyl-[acp domain within a fatty acid synthase]→a (2E)-docos-2-enoyl-[acp domain within a fatty acid synthase] + H2O
(EC 2.3.1.86)
No genes
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyoctadecanoyl-[acp]→a (2E)-octadec-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
GFF4904
Fatty-acyl-CoA synthase (in reverse):
a (2E)-docos-2-enoyl-[acp domain within a fatty acid synthase] + NADPH + H+→a docosanoyl-[acp domain within a fatty acid synthase] + NADP+
(EC 2.3.1.86)
No genes
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-octadec-2-enoyl-[acp] + NADH + H+→a stearoyl-[acp] + NAD+
(EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
Beta-ketoacyl-acyl-carrier-protein synthase I:
a stearoyl-[acp] + a malonyl-[acp] + H+→a 3-oxoicosanoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.41)
GFF3009
GFF4995
Fatty-acyl-CoA synthase:
a docosanoyl-[acp domain within a fatty acid synthase] + malonyl-CoA + H+→a 3-oxotetracosanoyl-[acp domain within a fatty acid synthase] + CO2 + coenzyme A
(EC 2.3.1.86)
No genes
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxoicosanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyicosanoyl-[acp] + NADP+
(EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
Fatty-acyl-CoA synthase (in reverse):
a 3-oxotetracosanoyl-[acp domain within a fatty acid synthase] + NADPH + H+→a (3R)-3-hydroxytetracosanoyl-[acp domain within a fatty acid synthase] + NADP+
(EC 2.3.1.86)
No genes
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyicosanoyl-[acp]→a (2E)-icos-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
GFF4904
Fatty-acyl-CoA synthase:
a (3R)-3-hydroxytetracosanoyl-[acp domain within a fatty acid synthase]→a (2E)-tetracos-2-enoyl-[acp domain within a fatty acid synthase] + H2O
(EC 2.3.1.86)
No genes
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-icos-2-enoyl-[acp] + NADH + H+→an arachidoyl-[acp] + NAD+
(EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
Fatty-acyl-CoA synthase (in reverse):
a (2E)-tetracos-2-enoyl-[acp domain within a fatty acid synthase] + NADH + H+→a lignoceroyl-[acp domain within a fatty acid synthase] + NAD+
(EC 2.3.1.86)
No genes
Fatty-acyl-CoA synthase:
a lignoceroyl-[acp domain within a fatty acid synthase] + malonyl-CoA + H+→a 3-oxohexacosanoyl-[acp domain within a fatty acid synthase] + CO2 + coenzyme A
(EC 2.3.1.86)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase I:
an arachidoyl-[acp] + a malonyl-[acp] + H+→a 3-oxodocosanoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.41)
GFF3009
GFF4995
Fatty-acyl-CoA synthase (in reverse):
a 3-oxohexacosanoyl-[acp domain within a fatty acid synthase] + NADPH + H+→a (3R)-3-hydroxyhexacosanoyl-[acp domain within a fatty acid synthase] + NADP+
(EC 2.3.1.86)
No genes
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxodocosanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxydocosanoyl-[acp] + NADP+
(EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
Fatty-acyl-CoA synthase:
a (3R)-3-hydroxyhexacosanoyl-[acp domain within a fatty acid synthase]→a (2E)-hexacos-2-enoyl-[acp domain within a fatty acid synthase] + H2O
(EC 2.3.1.86)
No genes
a (3R)-3-hydroxydocosanoyl-[acp]→a (2E)-docos-2-enoyl-[acp] + H2O (EC 4.2.1.M1)
No genes
Fatty-acyl-CoA synthase (in reverse):
a (2E)-hexacos-2-enoyl-[acp domain within a fatty acid synthase] + NADPH + H+→a cerotoyl-[acp domain within a fatty acid synthase] + NADP+
(EC 2.3.1.86)
No genes
Trans-2-decenoyl-[acyl-carrier-protein] isomerase:
a (2E)-docos-2-enoyl-[acp]→a (3Z)-docos-3-enoyl-[acp]
(EC 5.3.3.14)
No genes
a (3Z)-docos-3-enoyl-[acp] + a malonyl-[acp] + H+→a (5Z)-3-oxotetracos-5-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.293)
No genes
Fatty-acyl-CoA synthase:
a cerotoyl-[acp domain within a fatty acid synthase] + coenzyme A→cerotoyl-CoA + an [acyl carrier protein] domain within a fatty acid synthase
(EC 2.3.1.86)
No genes
Propionyl-CoA carboxylase:
cerotoyl-CoA + ATP + hydrogen carbonate→2-carboxycerotoyl-CoA + ADP + H+ + phosphate
(EC 6.4.1.3)
GFF4785
GFF4786
a (5Z)-3-oxotetracos-5-enoyl-[acp] + NADPH + H+→a (3R,5Z)-3-hydroxytetracos-5-enoyl-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a (3R,5Z)-3-hydroxytetracos-5-enoyl-[acp]→a (2E,5Z)-tetracosa-2,5-dienoyl-[acp] + H2O (EC 4.2.1.M1)
No genes
a (2E,5Z)-tetracosa-2,5-dienoyl-[acp] + NADH + H+→a (5Z)-tetracos-5-enoyl-[acp] + NAD+ (EC 1.3.1.118)
No genes
a (5Z)-tetracos-5-enoyl-[acp] + a malonyl-[acp] + H+→a (7Z)-3-oxohexacos-7-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.293)
No genes
a (7Z)-3-oxohexacos-7-enoyl-[acp] + NADPH + H+→a (3R,7Z)-3-hydroxyhexacos-7-enoyl-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a (3R,7Z)-3-hydroxyhexacos-7-enoyl-[acp]→a (2E,7Z)-hexacosa-2,7-dienoyl-[acp] + H2O (EC 4.2.1.M1)
No genes
a (2E,7Z)-hexacosa-2,7-dienoyl-[acp] + NADH + H+→a (7Z)-hexacos-7-enoyl-[acp] + NAD+ (EC 1.3.1.118)
No genes
a (7Z)-hexacos-7-enoyl-[acp] + a malonyl-[acp] + H+→a (9Z)-3-oxooctacos-9-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.293)
No genes
a (9Z)-3-oxooctacos-9-enoyl-[acp] + NADPH + H+→a cis-delta9-3-hydroxyC28:1-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis-delta9-3-hydroxyC28:1-[acp]→a trans-delta2-cis-delta9-C28:2-[acp] + H2O (EC 4.2.1.M1)
No genes
a trans-delta2-cis-delta9-C28:2-[acp] + NADH + H+→a cis-delta9-C28:1-[acp] + NAD+ (EC 1.3.1.118)
No genes
a cis-delta9-C28:1-[acp] + a malonyl-[acp] + H+→a cis-delta11-3-oxo-C30:1-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.293)
No genes
a cis-delta11-3-oxo-C30:1-[acp] + NADPH + H+→a cis-delta11-3-hydroxyC30:1-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis-delta11-3-hydroxyC30:1-[acp]→a trans-delta2-cis-delta11-C30:2-[acp] + H2O (EC 4.2.1.M1)
No genes
a trans-delta2-cis-delta11-C30:2-[acp] + NADH + H+→a cis-delta11-C30:1-[acp] + NAD+ (EC 1.3.1.118)
No genes
a cis-delta11-C30:1-[acp] + a malonyl-[acp] + H+→a cis-delta13-3-oxo-C32:1-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.293)
No genes
a cis-delta13-3-oxo-C32:1-[acp] + NADPH + H+→a cis-delta13-3-hydroxyC32:1-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis-delta13-3-hydroxyC32:1-[acp]→a trans-delta2-cis-delta13-C32:2-[acp] + H2O (EC 4.2.1.M1)
No genes
a trans-delta2-cis-delta13-C32:2-[acp] + NADH + H+→a cis-delta13-C32:1-[acp] + NAD+ (EC 1.3.1.118)
No genes
a cis-delta13-C32:1-[acp] + a malonyl-[acp] + H+→a cis-delta15-3-oxo-C34:1-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.293)
No genes
a cis-delta15-3-oxo-C34:1-[acp] + NADPH + H+→a cis-delta15-3-hydroxyC34:1-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis-delta15-3-hydroxyC34:1-[acp]→a trans-delta2-cis-delta15-C34:2-[acp] + H2O (EC 4.2.1.M1)
No genes
a trans-delta2-cis-delta15-C34:2-[acp] + NADH + H+→a cis-delta15-C34:1-[acp] + NAD+ (EC 1.3.1.118)
No genes
Trans-2-decenoyl-[acyl-carrier-protein] isomerase:
a trans-delta2-cis-delta15-C34:2-[acp]→a cis,cis-delta3,15-C34:2-[acp]
(EC 5.3.3.14)
No genes
a cis,cis-delta3,15-C34:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta5,17-3-oxo-C36:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
a cis-delta15-C34:1-[acp] + a malonyl-[acp] + H+→a cis-delta17-3-oxo-C36:1-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.293)
No genes
a cis,cis-delta5,17-3-oxo-C36:2-[acp] + NADPH + H+→a cis,cis-delta5,17-3-hydroxyC36:2[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis-delta17-3-oxo-C36:1-[acp] + NADPH + H+→a cis-delta17-3-hydroxyC36:1-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis,cis-delta5,17-3-hydroxyC36:2[acp]→a trans-delta2-cis,cis-5,17-C36:3-[acp] + H2O (EC 4.2.1.M1)
No genes
a cis-delta17-3-hydroxyC36:1-[acp]→a trans-delta2-cis-delta17-C36:2-[acp] + H2O (EC 4.2.1.M1)
No genes
a trans-delta2-cis,cis-5,17-C36:3-[acp] + NADH + H+→a cis,cis-delta5,17-C36:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
a trans-delta2-cis-delta17-C36:2-[acp] + NADH + H+→a cis-delta17-C36:1-[acp] + NAD+ (EC 1.3.1.118)
No genes
a cis-delta17-C36:1-[acp] + a malonyl-[acp] + H+→a cis-delta19-3-oxo-C38:1-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.293)
No genes
a cis,cis-delta5,17-C36:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta7,19-3-oxo-C38:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
a cis-delta19-3-oxo-C38:1-[acp] + NADPH + H+→a cis-delta19-3-hydroxyC38:1-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis,cis-delta7,19-3-oxo-C38:2-[acp] + NADPH + H+→a cis,cis-delta7,19-3-hydroxyC38:2-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis-delta19-3-hydroxyC38:1-[acp]→a trans-delta2-cis-delta19-C38:2-[acp] + H2O (EC 4.2.1.M1)
No genes
a cis,cis-delta7,19-3-hydroxyC38:2-[acp]→a trans-delta2-cis-cis-delta7-19-C38:3-[acp] + H2O (EC 4.2.1.M1)
No genes
a trans-delta2-cis-delta19-C38:2-[acp] + NADH + H+→a cis-delta19-C38:1-[acp] + NAD+ (EC 1.3.1.118)
No genes
a trans-delta2-cis-cis-delta7-19-C38:3-[acp] + NADH + H+→a cis,cis-delta7,19-C38:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
a cis-delta19-C38:1-[acp] + a malonyl-[acp] + H+→a cis-delta21-3-oxo-C40:1-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.293)
No genes
a cis,cis-delta7,19-C38:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta9,21-3-oxo-C40:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
a cis,cis-delta9,21-3-oxo-C40:2-[acp] + NADPH + H+→a cis,cis-delta9,21-3-hydroxyC40:2-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis-delta21-3-oxo-C40:1-[acp] + NADPH + H+→a cis-delta21-3-hydroxyC40:1-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis,cis-delta9,21-3-hydroxyC40:2-[acp]→a trans-delta2-cis,cis-9,21-C40:3-[acp] + H2O (EC 4.2.1.M1)
No genes
a cis-delta21-3-hydroxyC40:1-[acp]→a trans-delta2-cis-delta21-C40:2-[acp] + H2O (EC 4.2.1.M1)
No genes
a trans-delta2-cis,cis-9,21-C40:3-[acp] + NADH + H+→a cis,cis-delta9,21-C40:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
Trans-2-decenoyl-[acyl-carrier-protein] isomerase:
a trans-delta2-cis-delta21-C40:2-[acp]→a cis,cis-delta3,21-C40:2-[acp]
(EC 5.3.3.14)
No genes
a cis,cis-delta9,21-C40:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta11,23-3-oxo-C42:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
a cis,cis-delta3,21-C40:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta5,23-3-oxo-C42:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
a cis,cis-delta5,23-3-oxo-C42:2-[acp] + NADPH + H+→a cis,cis-delta5,23-3-hydroxyC42:2-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis,cis-delta11,23-3-oxo-C42:2-[acp] + NADPH + H+→a cis,cis-delta11,23-3-hydroxyC42:2-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis,cis-delta11,23-3-hydroxyC42:2-[acp]→a trans-delta2-cis,cis-delta11,23-C42:3-[acp] + H2O (EC 4.2.1.M1)
No genes
a cis,cis-delta5,23-3-hydroxyC42:2-[acp]→a trans-delta2-cis,cis-delta5,23-C42:3-[acp] + H2O (EC 4.2.1.M1)
No genes
a trans-delta2-cis,cis-delta11,23-C42:3-[acp] + NADH + H+→a cis,cis-delta11,23-C42:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
a trans-delta2-cis,cis-delta5,23-C42:3-[acp] + NADH + H+→a cis,cis-delta5,23-C42:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
a cis,cis-delta11,23-C42:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta13,25-3-oxo-C44:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
a cis,cis-delta5,23-C42:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta7,25-3-oxo-C44:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
a cis,cis-delta13,25-3-oxo-C44:2-[acp] + NADPH + H+→a cis,cis-delta13,25-3-hydroxyC44:2-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis,cis-delta7,25-3-oxo-C44:2-[acp] + NADPH + H+→a cis,cis-delta7,25-3-hydroxyC44:2-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis,cis-delta13,25-3-hydroxyC44:2-[acp]→a trans-delta2-cis,cis-delta13,25-C44:3-[acp] + H2O (EC 4.2.1.M1)
No genes
a cis,cis-delta7,25-3-hydroxyC44:2-[acp]→a trans-delta2-cis,cis-delta7,25-C44:3-[acp] + H2O (EC 4.2.1.M1)
No genes
a trans-delta2-cis,cis-delta13,25-C44:3-[acp] + NADH + H+→a cis,cis-delta13,25-C44:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
a trans-delta2-cis,cis-delta7,25-C44:3-[acp] + NADH + H+→a cis,cis-delta7,25-C44:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
a cis,cis-delta13,25-C44:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta15,27-3-oxo-C46:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
a cis,cis-delta7,25-C44:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta9,27-3-oxo-C46:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
a cis,cis-delta15,27-3-oxo-C46:2-[acp] + NADPH + H+→a cis,cis-delta15,27-3-hydroxyC46:2-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis,cis-delta9,27-3-oxo-C46:2-[acp] + NADPH + H+→a cis,cis-delta9,27-3-hydroxyC46:2-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis,cis-delta15,27-3-hydroxyC46:2-[acp]→a trans-delta2-cis,cis-delta15,27-C46:3-[acp] + H2O (EC 4.2.1.M2)
No genes
a cis,cis-delta9,27-3-hydroxyC46:2-[acp]→a trans-delta2-cis,cis-delta9,27-C46:3-[acp] + H2O (EC 4.2.1.M2)
No genes
a trans-delta2-cis,cis-delta15,27-C46:3-[acp] + NADH + H+→a cis,cis-delta15,27-C46:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
a trans-delta2-cis,cis-delta9,27-C46:3-[acp] + NADH + H+→a cis,cis-delta9,27-C46:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
a cis,cis-delta15,27-C46:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta17,29-3-oxo-C48:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
a cis,cis-delta9,27-C46:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta11,29-3-oxo-C48:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
a cis,cis-delta17,29-3-oxo-C48:2-[acp] + NADPH + H+→a cis,cis-delta17,29-3-hydroxyC48:2-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis,cis-delta11,29-3-oxo-C48:2-[acp] + NADPH + H+→a cis,cis-delta11,29-3-hydroxy C48:2-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis,cis-delta17,29-3-hydroxyC48:2-[acp]→a trans-delta2-cis,cis-delta17,29-C48:3-[acp] + H2O (EC 4.2.1.M2)
No genes
a cis,cis-delta11,29-3-hydroxy C48:2-[acp]→a trans-delta2-cis,cis-delta11,29-C48:3-[acp] + H2O (EC 4.2.1.M2)
No genes
a trans-delta2-cis,cis-delta17,29-C48:3-[acp] + NADH + H+→a cis,cis-delta17,29-C48:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
a trans-delta2-cis,cis-delta11,29-C48:3-[acp] + NADH + H+→a cis,cis-delta11,29-C48:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
a cis,cis-delta11,29-C48:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta13,31-3-oxo-C50:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
a cis,cis-delta17,29-C48:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta19,31-3-oxo-C50:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
a cis,cis-delta13,31-3-oxo-C50:2-[acp] + NADPH + H+→a cis,cis-delta13,31-3-hydroxy C50:2-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis,cis-delta19,31-3-oxo-C50:2-[acp] + NADPH + H+→a cis,cis-delta19,31-3-hydroxyC50:2-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis,cis-delta19,31-3-hydroxyC50:2-[acp]→a trans-delta2-cis,cis-delta19,31-C50:3-[acp] + H2O (EC 4.2.1.M2)
No genes
a cis,cis-delta13,31-3-hydroxy C50:2-[acp]→a trans-delta2-cis,cis-delta13,31-C50:3-[acp] + H2O (EC 4.2.1.M2)
No genes
a trans-delta2-cis,cis-delta19,31-C50:3-[acp] + NADH + H+→a cis,cis-delta19,31-C50:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
a trans-delta2-cis,cis-delta13,31-C50:3-[acp] + NADH + H+→a cis,cis-delta13,31-C50:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
a cis,cis-delta13,31-C50:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta15,33-3-oxo-C52:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
Cyclopropane-fatty-acyl-phospholipid synthase:
a cis,cis-delta19,31-C50:2-[acp] + 2 S-adenosyl-L-methionine→a C52-α-meroacyl-[acp] + 2 S-adenosyl-L-homocysteine + 2 H+
(EC 2.1.1.79)
GFF1766
a cis,cis-delta15,33-3-oxo-C52:2-[acp] + NADPH + H+→a cis,cis-delta15,33-3-hydroxy C52:2-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a C52-α-meroacyl-[acp] + ATP + H2O→C52-α-meroacyl-adenylate + a soluble [acyl-carrier protein] + diphosphate
No genes
a cis,cis-delta15,33-3-hydroxy C52:2-[acp]→a trans-delta2-cis,cis-delta15,33-C52:3-[acp] + H2O (EC 4.2.1.M2)
No genes
C52-α-meroacyl-adenylate + 2-carboxycerotoyl-CoA + polyketide synthase PKS13→a 3-oxo-C78-α-mycolate-[pks13] + AMP + CO2 + coenzyme A
No genes
a trans-delta2-cis,cis-delta15,33-C52:3-[acp] + NADH + H+→a cis,cis-delta15,33-C52:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
a 3-oxo-C78-α-mycolate-[pks13] + a reduced two electron carrier→a C78-α-mycolate-[pks13] + an oxidized electron carrier
No genes
a C78-α-mycolate-[pks13] + D-mannopyranosyl-1-phosphoheptaprenol→6-O-mycolyl-β-D-mannopyranosyl-1-phosphoheptaprenol + polyketide synthase PKS13
No genes
a cis,cis-delta15,33-C52:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta17,35-3-oxo-C54:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
a cis,cis-delta17,35-3-oxo-C54:2-[acp] + NADPH + H+→a cis,cis-delta17,35-3-hydroxyC54:2-[acp] + NADP+ (EC 1.1.1.M9)
No genes
6-O-mycolyl-β-D-mannopyranosyl-1-phosphoheptaprenol + α,α-trehalose 6-phosphate→6-O-α-mycolyl-trehalose 6-phosphate + D-mannopyranosyl-1-phosphoheptaprenol
No genes
Trehalose-phosphatase:
6-O-α-mycolyl-trehalose 6-phosphate + H2O→α, α'-trehalose 6-α-mycolate + phosphate
(EC 3.1.3.12)
GFF1622
a cis,cis-delta17,35-3-hydroxyC54:2-[acp]→a trans-delta2-cis,cis-delta17,35-C54:3-[acp] + H2O (EC 4.2.1.M2)
No genes
α, α'-trehalose 6-α-mycolate[in] + ATP[in] + H2O[in]→α, α'-trehalose 6-α-mycolate[out] + ADP[in] + H+[in] + phosphate[in]
No genes
a trans-delta2-cis,cis-delta17,35-C54:3-[acp] + NADH + H+→a cis,cis-delta17,35-C54:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
α, α'-trehalose 6-α-mycolate + a mycobacterial arabinogalactan→a mycolyl-arabinogalactan-peptidoglycan complex + α,α-trehalose
No genes
a cis,cis-delta17,35-C54:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta19,37-3-oxo-C56:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
Trehalose O-mycolyltransferase:
2 α, α'-trehalose 6-α-mycolate→α, α'-trehalose 6,6'-bismycolate + α,α-trehalose
(EC 2.3.1.122)
No genes
a cis,cis-delta19,37-3-oxo-C56:2-[acp] + NADPH + H+→a cis,cis-delta19,37-3-hydroxy-C56:2-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a cis,cis-delta19,37-3-hydroxy-C56:2-[acp]→a trans-delta2-cis,cis-delta19,37-C56:3-[acp] + H2O (EC 4.2.1.M2)
No genes
a trans-delta2-cis,cis-delta19,37-C56:3-[acp] + NADH + H+→a cis,cis-delta19-37-C56:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
a cis,cis-delta19-37-C56:2-[acp] + S-adenosyl-L-methionine + H2O→a cis-delta19-37-hydroxy-38-methyl-C57:1-[acp] + S-adenosyl-L-homocysteine + H+
No genes
a cis,cis-delta19-37-C56:2-[acp] + a malonyl-[acp] + H+→a cis,cis-delta21,39-3-oxo-C58:2-[acp] + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.294)
No genes
a cis-delta19-37-hydroxy-38-methyl-C57:1-[acp] + S-adenosyl-L-methionine→a cis-delta19-37-methoxy-38-methyl-C57:1-[acp] + S-adenosyl-L-homocysteine + H+
No genes
a cis-delta19-37-hydroxy-38-methyl-C57:1-[acp] + S-adenosyl-L-methionine→a trans-delta18-37-hydroxy-20,38-dimethyl-C58:1-[acp] + S-adenosyl-L-homocysteine + H+
No genes
a cis,cis-delta21,39-3-oxo-C58:2-[acp] + NADPH + H+→a cis,cis-delta21,39-3-hydroxyC58:2-[acp] + NADP+ (EC 1.1.1.M9)
No genes
a trans-delta18-37-hydroxy-20,38-dimethyl-C58:1-[acp] + S-adenosyl-L-methionine→a trans-delta18-37-methoxy-20,38-dimethyl-C58:1-[acp] + S-adenosyl-L-homocysteine + H+
No genes
Cyclopropane-fatty-acyl-phospholipid synthase:
a cis-delta19-37-methoxy-38-methyl-C57:1-[acp] + S-adenosyl-L-methionine→a cis-methoxy-C59-meroacyl-[acp] + S-adenosyl-L-homocysteine + H+
(EC 2.1.1.79)
GFF1766
a cis,cis-delta21,39-3-hydroxyC58:2-[acp]→a trans-delta2-cis,cis-delta21,39-C58:3-[acp] + H2O (EC 4.2.1.M2)
No genes
a trans-delta18-37-methoxy-20,38-dimethyl-C58:1-[acp] + S-adenosyl-L-methionine→a 18-trans-cyclopropyl-37-methoxy-20,38-dimethyl-C60-meroacyl-[acp] + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.M101)
No genes
a cis-methoxy-C59-meroacyl-[acp] + ATP + H2O→a cis-methoxy-C59-meroacyl-adenylate + a soluble [acyl-carrier protein] + diphosphate
No genes
a trans-delta2-cis,cis-delta21,39-C58:3-[acp] + NADH + H+→a cis,cis-delta21,39-C58:2-[acp] + NAD+ (EC 1.3.1.118)
No genes
a cis,cis-delta21,39-C58:2-[acp] + S-adenosyl-L-methionine + H2O→a cis-delta21-39-hydroxy-40-methyl-C59:1-[acp] + S-adenosyl-L-homocysteine + H+
No genes
a 18-trans-cyclopropyl-37-methoxy-20,38-dimethyl-C60-meroacyl-[acp] + ATP + H2O→a trans-methoxy-C60-meroacyl-adenylate + a soluble [acyl-carrier protein] + diphosphate
No genes
a cis-methoxy-C59-meroacyl-adenylate + 2-carboxycerotoyl-CoA + polyketide synthase PKS13→a 3-oxo-C85-cis-methoxy-mycolate-[pks13] + AMP + CO2 + coenzyme A
No genes
a cis-delta21-39-hydroxy-40-methyl-C59:1-[acp] + an oxidized electron carrier→a cis-delta21-39-oxo-40-methyl-C59:1-[acp] + a reduced two electron carrier
No genes
a 3-oxo-C85-cis-methoxy-mycolate-[pks13] + a reduced two electron carrier→a C85-cis-methoxy-mycolate-[pks13] + an oxidized electron carrier
No genes
a trans-methoxy-C60-meroacyl-adenylate + 2-carboxycerotoyl-CoA + polyketide synthase PKS13→a 3-oxo-C86-trans-methoxy-mycolate-[pks13] + AMP + CO2 + coenzyme A
No genes
a cis-delta21-39-hydroxy-40-methyl-C59:1-[acp] + S-adenosyl-L-methionine→a trans-delta20-39-hydroxy-40-methyl-C60:1-[acp] + S-adenosyl-L-homocysteine + H+
No genes
a trans-delta20-39-hydroxy-40-methyl-C60:1-[acp] + an oxidized electron carrier→a trans-delta20-39-oxo-40-methyl-C60:1-[acp] + a reduced two electron carrier
No genes
a 3-oxo-C86-trans-methoxy-mycolate-[pks13] + a reduced two electron carrier→a C86-trans-methoxy-mycolate-[pks13] + an oxidized electron carrier
No genes
a C85-cis-methoxy-mycolate-[pks13] + D-mannopyranosyl-1-phosphoheptaprenol→6-O-cis-methoxy-mycolyl-β-D-mannopyranosyl-1-phosphoheptaprenol + polyketide synthase PKS13
No genes
Cyclopropane-fatty-acyl-phospholipid synthase:
a cis-delta21-39-oxo-40-methyl-C59:1-[acp] + S-adenosyl-L-methionine→a cis-keto-C60-meroacyl-[acp] + S-adenosyl-L-homocysteine + H+
(EC 2.1.1.79)
GFF1766
a C86-trans-methoxy-mycolate-[pks13] + D-mannopyranosyl-1-phosphoheptaprenol→6-O-trans-methoxy-mycolyl-β-D-mannopyranosyl-1-phosphoheptaprenol + polyketide synthase PKS13
No genes
a trans-delta20-39-oxo-40-methyl-C60:1-[acp]→a trans-keto-C61-meroacyl-[acp]
No genes
a cis-keto-C60-meroacyl-[acp] + ATP + H2O→a cis-keto-C60-meroacyl-adenylate + a soluble [acyl-carrier protein] + diphosphate
No genes
6-O-cis-methoxy-mycolyl-β-D-mannopyranosyl-1-phosphoheptaprenol + α,α-trehalose 6-phosphate→6-O-cis-methoxy-mycolyl-trehalose 6-phosphate + D-mannopyranosyl-1-phosphoheptaprenol
No genes
Trehalose-phosphatase:
6-O-cis-methoxy-mycolyl-trehalose 6-phosphate + H2O→trehalose-cis-methoxy-mono-mycolate + phosphate
(EC 3.1.3.12)
GFF1622
2-carboxycerotoyl-CoA + a cis-keto-C60-meroacyl-adenylate + polyketide synthase PKS13→a 3-oxo-C86-cis-keto-mycolate-[pks13] + AMP + CO2 + coenzyme A
No genes
a trans-keto-C61-meroacyl-[acp] + ATP + H2O→a trans-keto-C61-meroacyl-adenylate + a soluble [acyl-carrier protein] + diphosphate
No genes
6-O-trans-methoxy-mycolyl-β-D-mannopyranosyl-1-phosphoheptaprenol + α,α-trehalose 6-phosphate→6-O-trans-methoxy-mycolyl-trehalose 6-phosphate + D-mannopyranosyl-1-phosphoheptaprenol
No genes
Trehalose-phosphatase:
6-O-trans-methoxy-mycolyl-trehalose 6-phosphate + H2O→trehalose-trans-methoxy-mono-mycolate + phosphate
(EC 3.1.3.12)
GFF1622
a 3-oxo-C86-cis-keto-mycolate-[pks13] + a reduced two electron carrier→a C86-cis-keto-mycolate-[pks13] + an oxidized electron carrier
No genes
2-carboxycerotoyl-CoA + a trans-keto-C61-meroacyl-adenylate + polyketide synthase PKS13→a 3-oxo-C87-trans-keto-mycolate-[pks13] + AMP + CO2 + coenzyme A
No genes
trehalose-cis-methoxy-mono-mycolate[in] + ATP[in] + H2O[in]→trehalose-cis-methoxy-mono-mycolate[out] + ADP[in] + H+[in] + phosphate[in]
No genes
2 trehalose-cis-methoxy-mono-mycolate→trehalose-cis-methoxy-di-mycolate + α,α-trehalose
No genes
a 3-oxo-C87-trans-keto-mycolate-[pks13] + a reduced two electron carrier→a C87-trans-keto-mycolate-[pks13] + an oxidized electron carrier
No genes
trehalose-cis-methoxy-mono-mycolate + a mycobacterial arabinogalactan→arabinogalactan-cis-methoxy-mycolate + α,α-trehalose
No genes
a C86-cis-keto-mycolate-[pks13] + D-mannopyranosyl-1-phosphoheptaprenol→6-O-cis-keto-mycolyl-β-D-mannopyranosyl-1-phosphoheptaprenol + polyketide synthase PKS13
No genes
trehalose-trans-methoxy-mono-mycolate[in] + ATP[in] + H2O[in]→trehalose-trans-methoxy-mono-mycolate[out] + ADP[in] + H+[in] + phosphate[in]
No genes
2 trehalose-trans-methoxy-mono-mycolate→trehalose-trans-methoxy-di-mycolate + α,α-trehalose
No genes
trehalose-trans-methoxy-mono-mycolate + a mycobacterial arabinogalactan→arabinogalactan-trans-methoxy-mycolate + α,α-trehalose
No genes
a C87-trans-keto-mycolate-[pks13] + D-mannopyranosyl-1-phosphoheptaprenol→6-O-trans-keto-mycolyl-β-D-mannopyranosyl-1-phosphoheptaprenol + polyketide synthase PKS13
No genes
6-O-cis-keto-mycolyl-β-D-mannopyranosyl-1-phosphoheptaprenol + α,α-trehalose 6-phosphate→6-O-cis-keto-mycolyl-trehalose 6-phosphate + D-mannopyranosyl-1-phosphoheptaprenol
No genes
Trehalose-phosphatase:
6-O-cis-keto-mycolyl-trehalose 6-phosphate + H2O→trehalose-cis-keto-mono-mycolate + phosphate
(EC 3.1.3.12)
GFF1622
6-O-trans-keto-mycolyl-β-D-mannopyranosyl-1-phosphoheptaprenol + α,α-trehalose 6-phosphate→6-O-trans-keto-mycolyl-trehalose 6-phosphate + D-mannopyranosyl-1-phosphoheptaprenol
No genes
Trehalose-phosphatase:
6-O-trans-keto-mycolyl-trehalose 6-phosphate + H2O→trehalose-trans-keto-mono-mycolate + phosphate
(EC 3.1.3.12)
GFF1622
trehalose-cis-keto-mono-mycolate[in] + ATP[in] + H2O[in]→trehalose-cis-keto-mono-mycolate[out] + ADP[in] + H+[in] + phosphate[in]
No genes
2 trehalose-cis-keto-mono-mycolate→trehalose-cis-keto-di-mycolate + α,α-trehalose
No genes
trehalose-cis-keto-mono-mycolate + a mycobacterial arabinogalactan→arabinogalactan-cis-keto-mycolate + α,α-trehalose
No genes
trehalose-trans-keto-mono-mycolate[in] + ATP[in] + H2O[in]→trehalose-trans-keto-mono-mycolate[out] + ADP[in] + H+[in] + phosphate[in]
No genes
2 trehalose-trans-keto-mono-mycolate→trehalose-trans-keto-di-mycolate + α,α-trehalose
No genes
trehalose-trans-keto-mono-mycolate + a mycobacterial arabinogalactan→arabinogalactan-trans-keto-mycolate + α,α-trehalose
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information