MetaCyc Pathway: dipicolinate biosynthesis in Hydrogenophaga sp. GW460-11-11-14-LB1

Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)

Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H⁺→L-aspartate 4-semialdehyde + NADP⁺ + phosphate (EC 1.2.1.11)

GFF3359

L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H⁺ + H₂O (EC 4.3.3.7)

(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD⁺→dipicolinate + NADH + H⁺ + H₂O

No genes

Links:

Pathway details at MetaCyc
Fitness data for 7 genes
Select organism:
All MetaCyc pathways for Hydrogenophaga sp. GW460-11-11-14-LB1

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information