MetaCyc Pathway: crotonate fermentation (to acetate and cyclohexane carboxylate) in Hydrogenophaga sp. GW460-11-11-14-LB1

Add experiment(s):


acetyl-CoA + crotonate→acetate + crotonyl-CoA
No genes
crotonyl-CoA + CO2→(E)-glutaconyl-CoA + H+ (EC 1.3.8.6)
No genes
crotonyl-CoA + H2O→(S)-3-hydroxybutanoyl-CoA (EC 4.2.1.150)
GFF1003
GFF1566
GFF2070
GFF2072
GFF2109
GFF2111
GFF238
GFF2746
GFF2842
GFF2897
GFF2983
GFF3034
GFF3054
GFF3395
GFF3472
GFF3784
GFF4130
GFF414
GFF418
GFF4348
GFF435
GFF436
GFF4405
GFF4416
GFF4496
GFF4592
GFF4819
GFF482
GFF513
GFF5528
GFF5614
GFF5622
GFF5663
GFF5664
GFF5669
GFF5848
GFF5853
GFF5854
GFF619
GFF620
GFF726
GFF882
GFF915
GFF918
GFF931
GFF969
GFF979
(E)-glutaconyl-CoA + a reduced electron-transfer flavoprotein→glutaryl-CoA + an oxidized electron-transfer flavoprotein + H+ (EC 1.3.8.6)
No genes
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD+→acetoacetyl-CoA + NADH + H+ (EC 1.1.1.35)
GFF2109
GFF376
GFF3825
GFF414
GFF4497
GFF4592
GFF4826
GFF5620
GFF5662
GFF875
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
GFF1723
GFF2108
GFF3471
GFF3554
GFF3722
GFF3782
GFF3813
GFF415
GFF429
GFF437
GFF4593
GFF4796
GFF4825
GFF5621
GFF5633
GFF5665
GFF5843
GFF678
GFF876
GFF906
acetyl-CoA + glutaryl-CoA→3-oxopimeloyl-CoA + coenzyme A
GFF4593
3-hydroxypimeloyl-CoA dehydrogenase (in reverse):
3-oxopimeloyl-CoA + NADH + H+→3-hydroxypimeloyl-CoA + NAD+ (EC 1.1.1.259)
No genes
Acetate--CoA ligase (ADP-forming) (in reverse):
acetyl-CoA + ADP + phosphate→acetate + ATP + coenzyme A (EC 6.2.1.13)
No genes
3-hydroxypimeloyl-CoA + H+→2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O (EC 3.7.1.21)
No genes
2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA→6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O (EC 3.7.1.21)
No genes
6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H+→6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+ (EC 1.1.1.368)
No genes
Cyclohexa-1,5-dienecarbonyl-CoA hydratase:
6-hydroxycyclohex-1-ene-1-carbonyl-CoA→cyclohex-1,5-diene-1-carbonyl-CoA + H2O (EC 4.2.1.100)
No genes
cyclohex-1,5-diene-1-carbonyl-CoA + a reduced electron-transfer flavoprotein→cyclohex-1-ene-1-carbonyl-CoA + an oxidized electron-transfer flavoprotein + H+ (EC 1.3.8.10)
No genes
cyclohex-1-ene-1-carbonyl-CoA + a reduced electron-transfer flavoprotein→cyclohexane-1-carbonyl-CoA + an oxidized electron-transfer flavoprotein + H+ (EC 1.3.8.11)
GFF978
cyclohexane-1-carbonyl-CoA + H2O→cyclohexane-1-carboxylate + coenzyme A + H+
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information