MetaCyc Pathway: isopropanol biosynthesis (engineered) in Hydrogenophaga sp. GW460-11-11-14-LB1

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Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
No genes
Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
GFF1723
GFF2108
GFF3471
GFF3554
GFF3722
GFF3782
GFF3813
GFF415
GFF429
GFF437
GFF4593
GFF4796
GFF4825
GFF5621
GFF5633
GFF5665
GFF5843
GFF678
GFF876
GFF906
Acetoacetyl-CoA hydrolase:
acetoacetyl-CoA + H2O→acetoacetate + coenzyme A + H+ (EC 3.1.2.11)
No genes
Acetoacetate decarboxylase:
acetoacetate + H+→acetone + CO2 (EC 4.1.1.4)
No genes
Isopropanol dehydrogenase (NADP(+)) (in reverse):
acetone + NADPH + H+→propan-2-ol + NADP+ (EC 1.1.1.80)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information