MetaCyc Pathway: superpathway of L-tyrosine biosynthesis in Hydrogenophaga sp. GW460-11-11-14-LB1

3-deoxy-7-phosphoheptulonate synthase: D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)

GFF2125

GFF581

3-dehydroquinate synthase: 3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)

GFF1331

3-dehydroquinate dehydratase: 3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)

GFF3861

GFF434

GFF4984

GFF5233

GFF5442

Shikimate dehydrogenase (in reverse): 3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)

GFF5018

GFF5226

GFF5234

GFF5385

Shikimate kinase: shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)

GFF1204

GFF1332

3-phosphoshikimate 1-carboxyvinyltransferase: shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)

GFF5345

Chorismate synthase: 5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)

GFF5239

Chorismate mutase: chorismate→prephenate (EC 5.4.99.5)

GFF5343

Prephenate dehydrogenase: prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)

GFF5344

Aspartate transaminase (in reverse): 3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)

GFF1313

GFF1493

GFF1749

GFF2040

GFF3675

GFF3934

GFF4006

GFF4304

GFF4777

GFF4839

GFF5171

GFF5390

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information