MetaCyc Pathway: 8-amino-7-oxononanoate biosynthesis I in Hydrogenophaga sp. GW460-11-11-14-LB1

Add experiment(s):


a malonyl-[acp] + S-adenosyl-L-methionine→a malonyl-[acp] methyl ester + S-adenosyl-L-homocysteine (EC 2.1.1.197)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a malonyl-[acp] + a malonyl-[acp] methyl ester + H+→a 3-oxoglutaryl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
GFF2998
GFF3009
GFF3337
GFF4995
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxoglutaryl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxyglutaryl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyglutaryl-[acp] methyl ester→a (2E)-enoylglutaryl-[acp] methyl ester + H2O (EC 4.2.1.59)
GFF4904
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylglutaryl-[acp] methyl ester + NADH + H+→a glutaryl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
Beta-ketoacyl-acyl-carrier-protein synthase II:
a glutaryl-[acp] methyl ester + a malonyl-[acp] + H+→a 3-oxopimeloyl-[acp] methyl ester + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.179; 2.3.1.41)
GFF2998
GFF3009
GFF3337
GFF4995
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxopimeloyl-[acp] methyl ester + NADPH + H+→a (3R)-3-hydroxypimeloyl-[acp] methyl ester + NADP+ (EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxypimeloyl-[acp] methyl ester→a (2E)-enoylpimeloyl-[acp] methyl ester + H2O (EC 4.2.1.59)
GFF4904
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-enoylpimeloyl-[acp] methyl ester + NADH + H+→a pimeloyl-[acp] methyl ester + NAD+ (EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
a pimeloyl-[acp] methyl ester + H2O→a pimeloyl-[acp] + methanol + H+ (EC 3.1.1.85)
No genes
8-amino-7-oxononanoate synthase:
a pimeloyl-[acp] + L-alanine + H+→(8S)-8-amino-7-oxononanoate + a soluble [acyl-carrier protein] + CO2 (EC 2.3.1.47)
GFF391
GFF3995

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information