MetaCyc Pathway: 4-hydroxybenzoate biosynthesis III (plants) in Hydrogenophaga sp. GW460-11-11-14-LB1

4-coumarate--CoA ligase: 4-coumarate + ATP + coenzyme A→(E)-4-coumaroyl-CoA + AMP + diphosphate (EC 6.2.1.12)

No genes

(E)-4-coumaroyl-CoA + H2O→3S-(4-hydroxyphenyl)-3-hydroxy-propanoyl-CoA (EC 4.1.2.61)

GFF3784

3-hydroxyacyl-CoA dehydrogenase: 3S-(4-hydroxyphenyl)-3-hydroxy-propanoyl-CoA + NAD+→3-(4-hydroxyphenyl)-3-oxo-propanoyl-CoA + NADH + H+ (EC 1.1.1.35)

GFF2109

GFF3825

GFF414

GFF4497

GFF4592

GFF4826

GFF5620

GFF5662

GFF875

Acetyl-CoA C-acyltransferase (in reverse): 3-(4-hydroxyphenyl)-3-oxo-propanoyl-CoA + coenzyme A→4-hydroxybenzoyl-CoA + acetyl-CoA (EC 2.3.1.16)

GFF1723

GFF2108

GFF3471

GFF3554

GFF3722

GFF3782

GFF3813

GFF415

GFF429

GFF437

GFF4593

GFF4796

GFF4825

GFF5621

GFF5633

GFF5665

GFF5843

GFF678

GFF876

GFF906

GFF928

4-hydroxybenzoyl-CoA thioesterase: 4-hydroxybenzoyl-CoA + H2O→4-hydroxybenzoate + coenzyme A + H+ (EC 3.1.2.23)

GFF3780

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information