MetaCyc Pathway: superpathway of fatty acids biosynthesis (E. coli) in Hydrogenophaga sp. GW460-11-11-14-LB1

Add experiment(s):


acetyl-CoA + a [carboxyl-carrier protein dimer]-N6-carboxybiotinyl-L-lysine→malonyl-CoA + a [biotin carboxyl-carrier-protein dimer]-N6-biotinyl-L-lysine (EC 2.1.3.15)
GFF3353
GFF5139
[Acyl-carrier-protein] S-malonyltransferase:
malonyl-CoA + a soluble [acyl-carrier protein]→a malonyl-[acp] + coenzyme A
(EC 2.3.1.39)
GFF3334
GFF4738
GFF4744
GFF4746
GFF4749
GFF4750
GFF4751
GFF4752
GFF4753
Beta-ketoacyl-acyl-carrier-protein synthase III:
acetyl-CoA + a malonyl-[acp] + H+→an acetoacetyl-[acp] + CO2 + coenzyme A
(EC 2.3.1.180)
GFF164
GFF3333
GFF4995
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
an acetoacetyl-[acp] + NADPH + H+→a (3R)-3-hydroxybutanoyl-[acp] + NADP+
(EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxybutanoyl-[acp]→a (2E)-but-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
GFF4904
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-but-2-enoyl-[acp] + NADH + H+→a butanoyl-[acp] + NAD+
(EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
Beta-ketoacyl-acyl-carrier-protein synthase II:
a butanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxohexanoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
GFF2998
GFF3009
GFF3337
GFF4995
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxohexanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyhexanoyl-[acp] + NADP+
(EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyhexanoyl-[acp]→a (2E)-hex-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
GFF4904
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-hex-2-enoyl-[acp] + NADH + H+→a hexanoyl-[acp] + NAD+
(EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
Beta-ketoacyl-acyl-carrier-protein synthase II:
a hexanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxooctanoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
GFF2998
GFF3009
GFF3337
GFF4995
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxooctanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyoctanoyl-[acp] + NADP+
(EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyoctanoyl-[acp]→a (2E)-oct-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
GFF4904
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-oct-2-enoyl-[acp] + NADH + H+→an octanoyl-[acp] + NAD+
(EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
Beta-ketoacyl-acyl-carrier-protein synthase II:
an octanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxodecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
GFF2998
GFF3009
GFF3337
GFF4995
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxodecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxydecanoyl-[acp] + NADP+
(EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydecanoyl-[acp]→a (2E)-dec-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
GFF4904
Trans-2-decenoyl-[acyl-carrier-protein] isomerase:
a (2E)-dec-2-enoyl-[acp]→a (3Z)-dec-3-enoyl-[acp]
(EC 5.3.3.14)
No genes
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-dec-2-enoyl-[acp] + NADH + H+→a decanoyl-[acp] + NAD+
(EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
Beta-ketoacyl-acyl-carrier-protein synthase II:
a decanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxododecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
GFF2998
GFF3009
GFF3337
GFF4995
Beta-ketoacyl-acyl-carrier-protein synthase II:
a (3Z)-dec-3-enoyl-[acp] + a malonyl-[acp] + H+→a (5Z)-3-oxododec-5-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
GFF2998
GFF3009
GFF3337
GFF4995
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxododecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxydodecanoyl-[acp] + NADP+
(EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a (5Z)-3-oxododec-5-enoyl-[acp] + NADPH + H+→a (3R,5Z)-3-hydroxydodec-5-enoyl-[acp] + NADP+
(EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxydodecanoyl-[acp]→a (2E)-dodec-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
GFF4904
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R,5Z)-3-hydroxydodec-5-enoyl-[acp]→a (2E,5Z)-dodeca-3,5-dienoyl-[acp] + H2O
(EC 4.2.1.59)
GFF4904
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-dodec-2-enoyl-[acp] + NADH + H+→a dodecanoyl-[acp] + NAD+
(EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E,5Z)-dodeca-3,5-dienoyl-[acp] + NADH + H+→a (5Z)-dodec-5-enoyl-[acp] + NAD+
(EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
Dodecanoyl-[acyl-carrier-protein] hydrolase:
a dodecanoyl-[acp][nil] + H2O[nil]→laurate[nil] + a soluble [acyl-carrier protein][nil] + H+[nil]
(EC 3.1.2.21)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a (5Z)-dodec-5-enoyl-[acp] + a malonyl-[acp] + H+→a (7Z)-3-oxotetradec-7-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
GFF2998
GFF3009
GFF3337
GFF4995
Beta-ketoacyl-acyl-carrier-protein synthase II:
a dodecanoyl-[acp] + a malonyl-[acp] + H+→a 3-oxotetradecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
GFF2998
GFF3009
GFF3337
GFF4995
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a (7Z)-3-oxotetradec-7-enoyl-[acp] + NADPH + H+→a (3R,7Z)-3-hydroxytetradec-7-enoyl-[acp] + NADP+
(EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
Butyrate--CoA ligase:
laurate + ATP + coenzyme A→lauroyl-CoA + AMP + diphosphate
(EC 6.2.1.2; 6.2.1.3)
GFF125
GFF1745
GFF2607
GFF340
GFF4967
GFF506
GFF5253
GFF5635
GFF5648
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxotetradecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxytetradecanoyl-[acp] + NADP+
(EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R,7Z)-3-hydroxytetradec-7-enoyl-[acp]→a (2E,7Z)-tetradeca-2,7-dienoyl-[acp] + H2O
(EC 4.2.1.59)
GFF4904
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxytetradecanoyl-[acp]→a (2E)-tetradec-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
GFF4904
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E,7Z)-tetradeca-2,7-dienoyl-[acp] + NADH + H+→a (7Z)-tetradec-7-enoyl-[acp] + NAD+
(EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-tetradec-2-enoyl-[acp] + NADH + H+→a myristoyl-[acp] + NAD+
(EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
Beta-ketoacyl-acyl-carrier-protein synthase II:
a (7Z)-tetradec-7-enoyl-[acp] + a malonyl-[acp] + H+→a (9Z)-3-oxohexadec-9-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
GFF2998
GFF3009
GFF3337
GFF4995
Beta-ketoacyl-acyl-carrier-protein synthase II:
a myristoyl-[acp] + a malonyl-[acp] + H+→a 3-oxohexadecanoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179; 2.3.1.41)
GFF2998
GFF3009
GFF3337
GFF4995
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a (9Z)-3-oxohexadec-9-enoyl-[acp] + NADPH + H+→a (3R,9Z)-3-hydroxyhexadec-9-enoyl-[acp] + NADP+
(EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
a 3-oxohexadecanoyl-[acp] + NADPH + H+→a (3R)-3-hydroxyhexadecanoyl-[acp] + NADP+
(EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R)-3-hydroxyhexadecanoyl-[acp]→a (2E)-hexadec-2-enoyl-[acp] + H2O
(EC 4.2.1.59)
GFF4904
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R,9Z)-3-hydroxyhexadec-9-enoyl-[acp]→a (2E,9Z)-hexadeca-2,9-dienoyl-[acp] + H2O
(EC 4.2.1.59)
GFF4904
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E,9Z)-hexadeca-2,9-dienoyl-[acp] + NADH + H+→a palmitoleoyl-[acp] + NAD+
(EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E)-hexadec-2-enoyl-[acp] + NADH + H+→a palmitoyl-[acp] + NAD+
(EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
Oleoyl-[acyl-carrier-protein] hydrolase:
a palmitoyl-[acp] + H2O→palmitate + a soluble [acyl-carrier protein] + H+
(EC 3.1.2.14)
No genes
Oleoyl-[acyl-carrier-protein] hydrolase:
a palmitoleoyl-[acp] + H2O→palmitoleate + a soluble [acyl-carrier protein] + H+
(EC 3.1.2.14)
No genes
Beta-ketoacyl-acyl-carrier-protein synthase II:
a palmitoleoyl-[acp] + a malonyl-[acp] + H+→an (11Z)-3-oxooctadec-11-enoyl-[acp] + a soluble [acyl-carrier protein] + CO2
(EC 2.3.1.179)
GFF2998
GFF3337
Long-chain-fatty-acid--CoA ligase:
palmitate + ATP + coenzyme A→palmitoyl-CoA + AMP + diphosphate
(EC 6.2.1.3)
GFF125
GFF1745
GFF2607
GFF340
GFF3724
GFF4131
GFF4967
GFF506
GFF5253
GFF5635
GFF5648
3-oxoacyl-[acyl-carrier-protein] reductase (in reverse):
an (11Z)-3-oxooctadec-11-enoyl-[acp] + NADPH + H+→a (3R,11Z)-3-hydroxyoctadec-11-enoyl-[acp] + NADP+
(EC 1.1.1.100)
GFF1008
GFF1019
GFF1025
GFF1358
GFF1533
GFF1541
GFF1542
GFF1559
GFF16
GFF2059
GFF2071
GFF2110
GFF2114
GFF2149
GFF2155
GFF2425
GFF2839
GFF2984
GFF3012
GFF3285
GFF3335
GFF3405
GFF3466
GFF3473
GFF3515
GFF3625
GFF3736
GFF3749
GFF3781
GFF408
GFF4317
GFF4375
GFF4600
GFF4827
GFF5014
GFF5387
GFF5391
GFF5499
GFF5548
GFF5603
GFF5668
GFF5695
GFF753
GFF925
GFF933
GFF942
GFF943
GFF959
GFF996
3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase:
a (3R,11Z)-3-hydroxyoctadec-11-enoyl-[acp]→a (2E,11Z)-octadeca-2,11-dienoyl-[acp] + H2O
(EC 4.2.1.59)
GFF4904
Enoyl-[acyl-carrier-protein] reductase (NADH) (in reverse):
a (2E,11Z)-octadeca-2,11-dienoyl-[acp] + NADH + H+→a cis-vaccenoyl-[acp] + NAD+
(EC 1.3.1.9)
GFF1831
GFF4322
GFF4334
GFF5852
Oleoyl-[acyl-carrier-protein] hydrolase:
a cis-vaccenoyl-[acp] + H2Ocis-vaccenate + a soluble [acyl-carrier protein] + H+
(EC 3.1.2.14)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information