MetaCyc Pathway: superpathway of sulfur amino acid biosynthesis (<i>Saccharomyces cerevisiae</i>) in Pectobacterium carotovorum WPP14

MetaCyc Pathway: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) in Pectobacterium carotovorum WPP14

Homoserine O-acetyltransferase:
L-homoserine + acetyl-CoA→O-acetyl-L-homoserine + coenzyme A (EC 2.3.1.31)

Sulfate adenylyltransferase:
sulfate + ATP + H⁺→adenosine 5'-phosphosulfate + diphosphate (EC 2.7.7.4)

Adenylyl-sulfate kinase:
adenosine 5'-phosphosulfate + ATP→3'-phosphoadenylyl-sulfate + ADP + H⁺ (EC 2.7.1.25)

Phosphoadenylyl-sulfate reductase (thioredoxin) (in reverse):
3'-phosphoadenylyl-sulfate + a reduced thioredoxin→sulfite + adenosine 3',5'-bisphosphate + an oxidized thioredoxin + 2 H⁺ (EC 1.8.4.8)

Sulfite reductase (NADPH) (in reverse):
sulfite + 3 NADPH + 5 H⁺→hydrogen sulfide + 3 NADP⁺ + 3 H₂O (EC 1.8.1.2)

O-acetylhomoserine aminocarboxypropyltransferase:
O-acetyl-L-homoserine + hydrogen sulfide→L-homocysteine + acetate + H⁺ (EC 2.5.1.49)

Cystathionine beta-synthase:
L-homocysteine + L-serine→L-cystathionine + H₂O (EC 4.2.1.22)

Cystathionine gamma-lyase:
L-cystathionine + H₂O→L-cysteine + 2-oxobutanoate + ammonium (EC 4.4.1.1)

Cystathionine gamma-synthase:
L-cysteine + O-succinyl-L-homoserine→L-cystathionine + H⁺ + succinate (EC 2.5.1.48)

Cysteine-S-conjugate beta-lyase:
L-cystathionine + H₂O→L-homocysteine + ammonium + pyruvate (EC 4.4.1.13)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information