MetaCyc Pathway: superpathway of ubiquinol-8 biosynthesis (early decarboxylation) in Pantoea agglomerans CFBP13505 P0401

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Chorismate lyase:
chorismate→4-hydroxybenzoate + pyruvate (EC 4.1.3.40)
PagCFBP13516_RS18150 (ubiC)
Dimethylallyltranstransferase:
prenyl diphosphate + 3-methylbut-3-en-1-yl diphosphate→geranyl diphosphate + diphosphate (EC 2.5.1.1)
PagCFBP13516_RS14985 (ispA)
PagCFBP13516_RS21005
Geranyltranstransferase:
geranyl diphosphate + 3-methylbut-3-en-1-yl diphosphate→(2E,6E)-farnesyl diphosphate + diphosphate (EC 2.5.1.10)
PagCFBP13516_RS14985 (ispA)
PagCFBP13516_RS21005
(2E,6E)-farnesyl diphosphate + 5 3-methylbut-3-en-1-yl diphosphate→all-trans-octaprenyl diphosphate + 5 diphosphate (EC 2.5.1.90)
PagCFBP13516_RS14985 (ispA)
PagCFBP13516_RS17395 (ispB)
PagCFBP13516_RS21005
4-hydroxybenzoate nonaprenyltransferase:
4-hydroxybenzoate + all-trans-octaprenyl diphosphate→4-hydroxy-3-octaprenylbenzoate + diphosphate (EC 2.5.1.39)
PagCFBP13516_RS18145 (ubiA)
4-hydroxy-3-octaprenylbenzoate + H+→2-octaprenylphenol + CO2 (EC 4.1.1.98)
PagCFBP13516_RS06470
PagCFBP13516_RS18490 (ubiD)
2-octaprenylphenol + NADPH + dioxygen + H+→3-(all-trans-octaprenyl)benzene-1,2-diol + NADP+ + H2O (EC 1.14.13.240)
PagCFBP13516_RS03990 (ubiI)
PagCFBP13516_RS18525 (ubiB)
3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine→2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.222)
PagCFBP13516_RS06675 (ubiG)
2-methoxy-6-(all-trans-octaprenyl)phenol + NADPH + dioxygen + H+→2-methoxy-6-all trans-octaprenyl-1,4-benzoquinol + NADP+ + H2O (EC 1.14.13.M56)
PagCFBP13516_RS03985 (ubiH)
2-methoxy-6-all trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-methionine→6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.201)
PagCFBP13516_RS18535 (ubiE)
6-methoxy-3-methyl-2-all-trans-octaprenyl-1,4-benzoquinol + a reduced two electron carrier + dioxygen→3-demethylubiquinol-8 + an oxidized electron carrier + H2O (EC 1.14.99.60)
PagCFBP13516_RS14050 (ubiF)
3-demethylubiquinone-9 3-O-methyltransferase:
3-demethylubiquinol-8 + S-adenosyl-L-methionine→ubiquinol-8 + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.64)
PagCFBP13516_RS06675 (ubiG)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information