MetaCyc Pathway: superpathway of L-threonine biosynthesis in Pantoea agglomerans CFBP13505 P0401

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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
PagCFBP13516_RS00080
PagCFBP13516_RS01090
PagCFBP13516_RS01115 (pdxR)
PagCFBP13516_RS03520
PagCFBP13516_RS03525
PagCFBP13516_RS06375 (pdxR)
PagCFBP13516_RS06560
PagCFBP13516_RS09780
PagCFBP13516_RS12850
PagCFBP13516_RS14200
PagCFBP13516_RS18340
PagCFBP13516_RS23715
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
PagCFBP13516_RS00880
PagCFBP13516_RS16525 (thrA)
PagCFBP13516_RS18205 (lysC)
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
PagCFBP13516_RS01670 (asd)
PagCFBP13516_RS06430
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
PagCFBP13516_RS00880
PagCFBP13516_RS16525 (thrA)
Homoserine kinase:
L-homoserine + ATP→O-phospho-L-homoserine + ADP + H+ (EC 2.7.1.39)
PagCFBP13516_RS16520 (thrB)
Threonine synthase:
O-phospho-L-homoserine + H2O→L-threonine + phosphate (EC 4.2.3.1)
PagCFBP13516_RS16515 (thrC)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information