MetaCyc Pathway: superpathway of L-tryptophan biosynthesis in Pantoea agglomerans CFBP13505 P0401

MetaCyc Pathway: superpathway of L-tryptophan biosynthesis in Pantoea agglomerans CFBP13505 P0401

3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H₂O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)

PagCFBP13505_RS03695

PagCFBP13505_RS16565

PagCFBP13505_RS17675

3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)

PagCFBP13505_RS21700

3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H₂O (EC 4.2.1.10)

PagCFBP13505_RS11010

PagCFBP13505_RS16835

Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H⁺→shikimate + NADP⁺ (EC 1.1.1.25)

PagCFBP13505_RS22560

Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H⁺ (EC 2.7.1.71)

PagCFBP13505_RS10220

PagCFBP13505_RS21705

3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)

PagCFBP13505_RS04470

Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)

PagCFBP13505_RS00105

Anthranilate synthase:
chorismate + L-glutamine→anthranilate + L-glutamate + H⁺ + pyruvate (EC 4.1.3.27)

PagCFBP13505_RS06995

PagCFBP13505_RS07000

PagCFBP13505_RS07005

Anthranilate phosphoribosyltransferase (in reverse):
anthranilate + 5-phospho-α-D-ribose 1-diphosphate→N-(5-phosphoribosyl)-anthranilate + diphosphate (EC 2.4.2.18)

PagCFBP13505_RS04030

PagCFBP13505_RS07005

Phosphoribosylanthranilate isomerase:
N-(5-phosphoribosyl)-anthranilate→1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (EC 5.3.1.24)

PagCFBP13505_RS07010

Indole-3-glycerol-phosphate synthase:
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H⁺→(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO₂ + H₂O (EC 4.1.1.48)

PagCFBP13505_RS07010

Indole-3-glycerol-phosphate lyase:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate→indole + D-glyceraldehyde 3-phosphate (EC 4.1.2.8; 4.2.1.20)

PagCFBP13505_RS07015

PagCFBP13505_RS07020

PagCFBP13505_RS12450

indole + L-serine→L-tryptophan + H₂O (EC 4.2.1.122; 4.2.1.20)

PagCFBP13505_RS07015

PagCFBP13505_RS07020

PagCFBP13505_RS12450

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information