MetaCyc Pathway: noradrenaline and adrenaline degradation in Pantoea agglomerans CFBP13505 P0401

Add experiment(s):


Catechol O-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→L-normetanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
(R)-noradrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
Phenylethanolamine N-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→(R)-adrenaline + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.28)
No genes
Monoamine oxidase:
(R)-adrenaline + dioxygen + H2O→3,4-dihydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
No genes
Catechol O-methyltransferase:
(R)-adrenaline + S-adenosyl-L-methionine→metanephrine + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Monoamine oxidase:
L-normetanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
No genes
Alcohol dehydrogenase (in reverse):
3,4-dihydroxyphenylglycolaldehyde + NADH + H+→(R)-3,4-dihydroxyphenylglycol + NAD+ (EC 1.1.1.1)
PagCFBP13516_RS01140
PagCFBP13516_RS03775 (acuI)
PagCFBP13516_RS07075
PagCFBP13516_RS08740 (adhP)
PagCFBP13516_RS09190 (adhE)
PagCFBP13516_RS14230
PagCFBP13516_RS16050
PagCFBP13516_RS18055
PagCFBP13516_RS19800
PagCFBP13516_RS22100 (ahr)
Aldehyde dehydrogenase (NAD(+)):
3,4-dihydroxyphenylglycolaldehyde + NAD+ + H2O→3,4-dihydroxymandelate + NADH + 2 H+ (EC 1.2.1.3)
PagCFBP13516_RS07745
PagCFBP13516_RS07755
PagCFBP13516_RS11740 (exaC)
Monoamine oxidase:
metanephrine + dioxygen + H2O→3-methoxy-4-hydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)
No genes
Catechol O-methyltransferase:
(R)-3,4-dihydroxyphenylglycol + S-adenosyl-L-methionine→3-methoxy-4-hydroxyphenylglycol + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Catechol O-methyltransferase:
3,4-dihydroxymandelate + S-adenosyl-L-methionine→vanillylmandelate + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.6)
No genes
Alcohol dehydrogenase:
3-methoxy-4-hydroxyphenylglycol + NAD+→3-methoxy-4-hydroxyphenylglycolaldehyde + NADH + H+ (EC 1.1.1.1)
PagCFBP13516_RS01140
PagCFBP13516_RS03775 (acuI)
PagCFBP13516_RS07075
PagCFBP13516_RS08740 (adhP)
PagCFBP13516_RS09190 (adhE)
PagCFBP13516_RS14230
PagCFBP13516_RS16050
PagCFBP13516_RS18055
PagCFBP13516_RS19800
PagCFBP13516_RS22100 (ahr)
Aldehyde dehydrogenase (NAD(+)):
3-methoxy-4-hydroxyphenylglycolaldehyde + NAD+ + H2O→vanillylmandelate + NADH + 2 H+ (EC 1.2.1.3)
PagCFBP13516_RS07745
PagCFBP13516_RS07755
PagCFBP13516_RS11740 (exaC)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information