MetaCyc Pathway: superpathway of L-methionine biosynthesis (transsulfuration) in Pantoea agglomerans CFBP13505 P0401

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Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
PagCFBP13516_RS00080
PagCFBP13516_RS01090
PagCFBP13516_RS01115 (pdxR)
PagCFBP13516_RS03520
PagCFBP13516_RS03525
PagCFBP13516_RS06375 (pdxR)
PagCFBP13516_RS06560
PagCFBP13516_RS09780
PagCFBP13516_RS12850
PagCFBP13516_RS14200
PagCFBP13516_RS18340
PagCFBP13516_RS23715
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
PagCFBP13516_RS00880
PagCFBP13516_RS16525 (thrA)
PagCFBP13516_RS18205 (lysC)
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
PagCFBP13516_RS01670 (asd)
PagCFBP13516_RS06430
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
PagCFBP13516_RS00880
PagCFBP13516_RS16525 (thrA)
Homoserine O-succinyltransferase:
L-homoserine + succinyl-CoA→O-succinyl-L-homoserine + coenzyme A (EC 2.3.1.46)
PagCFBP13516_RS18260 (metA)
Cystathionine gamma-synthase:
O-succinyl-L-homoserine + L-cysteine→L-cystathionine + H+ + succinate (EC 2.5.1.48)
PagCFBP13516_RS00875 (metB)
PagCFBP13516_RS16010
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate (EC 4.4.1.13)
PagCFBP13516_RS03455 (metC)
PagCFBP13516_RS10535
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate (EC 2.1.1.14)
PagCFBP13516_RS15135
PagCFBP13516_RS18560 (metE)
PagCFBP13516_RS21115
Methionine synthase:
L-homocysteine + a 5-methyltetrahydrofolate→L-methionine + a tetrahydrofolate (EC 2.1.1.13)
PagCFBP13516_RS18235 (metH)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information