MetaCyc Pathway: L-arginine biosynthesis I (via L-ornithine) in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

MetaCyc Pathway: L-arginine biosynthesis I (via L-ornithine) in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Carbamoyl-phosphate synthase (glutamine-hydrolyzing):
hydrogen carbonate + 2 ATP + L-glutamine + H₂O→carbamoyl phosphate + L-glutamate + 2 ADP + 2 H⁺ + phosphate (EC 6.3.5.5)

Amino-acid N-acetyltransferase:
L-glutamate + acetyl-CoA→N-acetyl-L-glutamate + coenzyme A + H⁺ (EC 2.3.1.1)

Acetylglutamate kinase:
N-acetyl-L-glutamate + ATP→N-acetylglutamyl-phosphate + ADP (EC 2.7.2.8)

N-acetyl-gamma-glutamyl-phosphate reductase (in reverse):
N-acetylglutamyl-phosphate + NADPH + H⁺→N-acetyl-L-glutamate 5-semialdehyde + NADP⁺ + phosphate (EC 1.2.1.38)

Acetylornithine transaminase (in reverse):
N-acetyl-L-glutamate 5-semialdehyde + L-glutamate→N-acetyl-L-ornithine + 2-oxoglutarate (EC 2.6.1.11)

Acetylornithine deacetylase:
N-acetyl-L-ornithine + H₂O→L-ornithine + acetate (EC 3.5.1.16)

Ornithine carbamoyltransferase:
carbamoyl phosphate + L-ornithine→L-citrulline + H⁺ + phosphate (EC 2.1.3.3)

Argininosuccinate synthase:
L-citrulline + L-aspartate + ATP→L-arginino-succinate + AMP + diphosphate + H⁺ (EC 6.3.4.5)

Argininosuccinate lyase:
L-arginino-succinate→L-arginine + fumarate (EC 4.3.2.1)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information