MetaCyc Pathway: superpathway of L-methionine biosynthesis (transsulfuration) in Klebsiella pneumoniae MRSN742743

Add experiment(s):


Aspartate transaminase (in reverse):
oxaloacetate + L-glutamate→L-aspartate + 2-oxoglutarate (EC 2.6.1.1)
GJGHJB_01113 (aRO8)
GJGHJB_01486 (alaA)
GJGHJB_02254 (aRO8)
GJGHJB_02767 (aspB)
GJGHJB_03288 (aspC)
GJGHJB_03683 (aRO8)
GJGHJB_03684 (aRO8)
GJGHJB_03829 (aRO8)
GJGHJB_03847 (aRO8)
GJGHJB_04382 (aRO8)
Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4)
GJGHJB_04275 (thrA)
GJGHJB_04727 (lysC)
GJGHJB_04906 (metL)
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11)
GJGHJB_00317 (asd)
GJGHJB_01458 (asd)
GJGHJB_02409 (asd)
Homoserine dehydrogenase (in reverse):
L-aspartate 4-semialdehyde + NAD(P)H + H+→L-homoserine + NAD(P)+ (EC 1.1.1.3)
GJGHJB_04275 (thrA)
GJGHJB_04906 (metL)
Homoserine O-succinyltransferase:
L-homoserine + succinyl-CoA→O-succinyl-L-homoserine + coenzyme A (EC 2.3.1.46)
GJGHJB_04738 (metA)
Cystathionine gamma-synthase:
O-succinyl-L-homoserine + L-cysteine→L-cystathionine + H+ + succinate (EC 2.5.1.48)
GJGHJB_04907 (metB)
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate (EC 4.4.1.13)
GJGHJB_00690 (metC)
GJGHJB_02660 (malY)
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase:
L-homocysteine + 5-methyltetrahydropteroyl tri-L-glutamate→L-methionine + tetrahydropteroyl tri-L-glutamate (EC 2.1.1.14)
GJGHJB_02027 (metE)
GJGHJB_02551 (metE)
GJGHJB_04811 (metE)
Methionine synthase:
L-homocysteine + a 5-methyltetrahydrofolate→L-methionine + a tetrahydrofolate (EC 2.1.1.13)
GJGHJB_04733 (metH)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information