MetaCyc Pathway: L-proline biosynthesis I (from L-glutamate) in Klebsiella pneumoniae MRSN742743

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Glutamate 5-kinase:
L-glutamate + ATP→γ-L-glutamyl 5-phosphate + ADP (EC 2.7.2.11)
KFA93_RS04285 (proB;go_component=cytoplasm|0005737||IEA;go_function=glutamate)
Glutamate-5-semialdehyde dehydrogenase (in reverse):
γ-L-glutamyl 5-phosphate + NADPH + H+→L-glutamate 5-semialdehyde + NADP+ + phosphate (EC 1.2.1.41)
KFA93_RS04290 (proA;go_function=glutamate-5-semialdehyde)
L-glutamate 5-semialdehyde→(S)-1-pyrroline-5-carboxylate + H+ + H2O (spontaneous)
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Pyrroline-5-carboxylate reductase (in reverse):
(S)-1-pyrroline-5-carboxylate + NAD(P)H + 2 H+→L-proline + NAD(P)+ (EC 1.5.1.2)
KFA93_RS04035 (proC;go_function=pyrroline-5-carboxylate)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information