MetaCyc Pathway: pyruvate fermentation to acetate and (<i>S</i>)-lactate I in Klebsiella pneumoniae MKP103

MetaCyc Pathway: pyruvate fermentation to acetate and (S)-lactate I in Klebsiella pneumoniae MKP103

L-lactate dehydrogenase (in reverse):
pyruvate + NADH + H⁺→(S)-lactate + NAD⁺ (EC 1.1.1.27)

pyruvate + coenzyme A + NAD⁺→acetyl-CoA + CO₂ + NADH (EC 1.2.1.104)

Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)

Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)

Links:

Pathway details at MetaCyc
Fitness data for 14 genes
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All MetaCyc pathways for Klebsiella pneumoniae MKP103

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information