MetaCyc Pathway: adipate biosynthesis in Escherichia coli BW25113

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3-oxoadipyl-CoA thiolase:
acetyl-CoA + succinyl-CoA→3-oxoadipoyl-CoA + coenzyme A
(EC 2.3.1.174)
b1397 (paaJ)
3-hydroxyacyl-CoA dehydrogenase (in reverse):
3-oxoadipoyl-CoA + NADH + H+→(3S)-hydroxyadipyl-CoA + NAD+
(EC 1.1.1.35)
b1395 (paaH)
b2341 (yfcX)
b3846 (fadB)
Enoyl-CoA hydratase:
(3S)-hydroxyadipyl-CoA→(2E)-5-carboxy-2-pentenoyl-CoA + H2O
(EC 4.2.1.17)
b1393 (paaF)
b1394 (paaG)
b2341 (yfcX)
b3846 (fadB)
(2E)-5-carboxy-2-pentenoyl-CoA + FADH2→adipoyl-CoA + FAD + H+
No genes
Succinate--CoA ligase (ADP-forming) (in reverse):
adipoyl-CoA + ADP + phosphate→adipate + ATP + coenzyme A
(EC 6.2.1.5)
b0728 (sucC)
b0729 (sucD)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information