MetaCyc Pathway: bile acids 7-O epimerization in Escherichia coli BW25113

Add experiment(s):


7-alpha-hydroxysteroid dehydrogenase:
cholate + NAD+→3α,12α-dihydroxy-7-oxo-5β-cholan-24-oate + NADH + H+ (EC 1.1.1.159)
b1619 (hdhA)
7-alpha-hydroxysteroid dehydrogenase:
chenodeoxycholate + NAD+→7-oxolithocholate + NADH + H+ (EC 1.1.1.159)
b1619 (hdhA)
7-beta-hydroxysteroid dehydrogenase (NADP(+)) (in reverse):
3α,12α-dihydroxy-7-oxo-5β-cholan-24-oate + NADPH + H+→ursocholate + NADP+ (EC 1.1.1.201)
No genes
7-beta-hydroxysteroid dehydrogenase (NADP(+)) (in reverse):
7-oxolithocholate + NADPH + H+→ursodeoxycholate + NADP+ (EC 1.1.1.201)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information