MetaCyc Pathway: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) in Escherichia coli BW25113

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Homoserine O-acetyltransferase:
L-homoserine + acetyl-CoA→O-acetyl-L-homoserine + coenzyme A (EC 2.3.1.31)
No genes
Sulfate adenylyltransferase:
sulfate + ATP + H+→adenosine 5'-phosphosulfate + diphosphate (EC 2.7.7.4)
b2751 (cysN)
b2752 (cysD)
Adenylyl-sulfate kinase:
adenosine 5'-phosphosulfate + ATP→3'-phosphoadenylyl-sulfate + ADP + H+ (EC 2.7.1.25)
b2750 (cysC)
Phosphoadenylyl-sulfate reductase (thioredoxin) (in reverse):
3'-phosphoadenylyl-sulfate + a reduced thioredoxin→sulfite + adenosine 3',5'-bisphosphate + an oxidized thioredoxin + 2 H+ (EC 1.8.4.8)
b2762 (cysH)
Sulfite reductase (NADPH) (in reverse):
sulfite + 3 NADPH + 5 H+→hydrogen sulfide + 3 NADP+ + 3 H2O (EC 1.8.1.2)
b2763 (cysI)
b2764 (cysJ)
O-acetylhomoserine aminocarboxypropyltransferase:
O-acetyl-L-homoserine + hydrogen sulfide→L-homocysteine + acetate + H+ (EC 2.5.1.49)
No genes
Cystathionine beta-synthase:
L-homocysteine + L-serine→L-cystathionine + H2O (EC 4.2.1.22)
No genes
Cystathionine gamma-lyase:
L-cystathionine + H2O→L-cysteine + 2-oxobutanoate + ammonium (EC 4.4.1.1)
No genes
Cystathionine gamma-synthase:
L-cysteine + O-succinyl-L-homoserine→L-cystathionine + H+ + succinate (EC 2.5.1.48)
b3939 (metB)
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate (EC 4.4.1.13)
b1622 (malY)
b3008 (metC)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information