MetaCyc Pathway: cytochrome c biogenesis (system I type) in Escherichia coli BW25113

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a reduced thioredoxin[in] + an [oxidized DsbD protein][membrane]→a [reduced DsbD protein][membrane] + an oxidized thioredoxin[in] (EC 1.8.4.16)
b3781 (trxA)
protoheme[in] + an oxidized electron carrier[membrane] + a CcmCDE complex[membrane] + H+[in]→a heme(III)-bound CcmCDE complex[out] + a reduced one electron carrier[membrane]
b2197 (ccmE)
b2198 (ccmD)
b2199 (ccmC)
an apo-[c-type cytochrome] with reduced L-cysteine residues[in]→an apo-[c-type cytochrome] with reduced L-cysteine residues[out]
b3705 (yidC)
a heme(III)-bound CcmCDE complex + ATP + a CcmAB complex→a heme(III)-bound CcmE protein + ADP + a CcmABCD complex + phosphate
b2200 (ccmB)
b2201 (ccmA)
a [reduced DsbD protein][membrane] + a CcmG protein with an internal disulfide bridge[out]→a CcmG protein with reduced cysteine residues[out] + an [oxidized DsbD protein][membrane] (EC 1.8.4.16)
b4136 (dipZ)
an apo-[c-type cytochrome] with reduced L-cysteine residues + an [oxidized DsbA protein]→an apo-[c-type cytochrome] with a dislufide bridge + a [reduced DsbA protein] (EC 1.8.4.15)
b3860 (dsbA)
an apo-[c-type cytochrome] with a dislufide bridge + a CcmG protein with reduced cysteine residues→an apo-[c-type cytochrome] with reduced L-cysteine residues + a CcmG protein with an internal disulfide bridge
b2195 (ccmG)
an apo-[c-type cytochrome] with reduced L-cysteine residues + a CcmH protein with an internal disulfide bridge→an apo-[c-type cytochrome]--CcmH disulfide
b2194 (ccmH)
a heme(III)-bound CcmE protein + an apo-[c-type cytochrome]--CcmH disulfide→a CcmE-[c-type cytochrome--CcmH disulfide] complex
b2196 (ccmF)
a CcmE-[c-type cytochrome--CcmH disulfide] complex + a CcmG protein with reduced cysteine residues + an electron-transfer quinol→a CcmH-CcmG disulfide + a c-type cytochrome + a c-type cytochrome biogenesis protein CcmE + an electron-transfer semiquinone + H+
b2195 (ccmG)
a CcmH-CcmG disulfide→a CcmH protein with reduced cysteine residues + a CcmG protein with an internal disulfide bridge
b2195 (ccmG)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information