MetaCyc Pathway: superpathway of guanosine nucleotides de novo biosynthesis I in Escherichia coli BW25113
| IMP dehydrogenase: IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205) |
| b2508 (guaB) |
| GMP synthase (glutamine-hydrolyzing): XMP + ATP + L-glutamine + H2O→GMP + AMP + L-glutamate + diphosphate + 2 H+ (EC 6.3.5.2) |
| b2507 (guaA) |
| Guanylate kinase: GMP + ATP→GDP + ADP (EC 2.7.4.8) |
| b3648 (gmk) |
| b4094 (phnN) |
| Nucleoside-diphosphate kinase: GDP + ATP→GTP + ADP (EC 2.7.4.6) |
| b0474 (adk) |
| b2518 (ndk) |
| Ribonucleoside-diphosphate reductase (in reverse): GDP + a reduced thioredoxin→dGDP + an oxidized thioredoxin + H2O (EC 1.17.4.1) |
| b2234 (nrdA) |
| b2235 (nrdB) |
| b2674 (nrdI) |
| b2675 (nrdE) |
| b2676 (nrdF) |
| Nucleoside-diphosphate kinase: dGDP + ATP→dGTP + ADP (EC 2.7.4.6) |
| b0474 (adk) |
| b2518 (ndk) |
Links:
- Pathway details at MetaCyc
- Fitness data for 11 genes
- All MetaCyc pathways for Escherichia coli BW25113
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information