MetaCyc Pathway: bile acids epimerization in Escherichia coli BW25113

Add experiment(s):


12-alpha-hydroxysteroid dehydrogenase:
cholate + NADP+→12-dehydrocholate + NADPH + H+ (EC 1.1.1.176)
No genes
7-alpha-hydroxysteroid dehydrogenase:
cholate + NAD+→3α,12α-dihydroxy-7-oxo-5β-cholan-24-oate + NADH + H+ (EC 1.1.1.159)
b1619 (hdhA)
3-alpha-hydroxycholanate dehydrogenase:
cholate + NAD+→3-dehydrocholate + NADH + H+ (EC 1.1.1.52)
No genes
7-alpha-hydroxysteroid dehydrogenase:
chenodeoxycholate + NAD+→7-oxolithocholate + NADH + H+ (EC 1.1.1.159)
b1619 (hdhA)
3-alpha-hydroxycholanate dehydrogenase:
chenodeoxycholate + NAD+→7α-hydroxy-3-oxo-5β-cholanate + NADH + H+ (EC 1.1.1.52)
No genes
12-alpha-hydroxysteroid dehydrogenase:
deoxycholate + NADP+→12-dehydrodeoxycholate + NADPH + H+ (EC 1.1.1.176)
No genes
12-beta-hydroxysteroid dehydrogenase (in reverse):
12-dehydrocholate + NADPH + H+→12-epicholate + NADP+ (EC 1.1.1.238)
No genes
7-beta-hydroxysteroid dehydrogenase (NADP(+)) (in reverse):
3α,12α-dihydroxy-7-oxo-5β-cholan-24-oate + NADPH + H+→ursocholate + NADP+ (EC 1.1.1.201)
No genes
3-dehydrocholate + NADH + H+→isocholate + NAD+ (EC 1.1.1.391)
No genes
7-beta-hydroxysteroid dehydrogenase (NADP(+)) (in reverse):
7-oxolithocholate + NADPH + H+→ursodeoxycholate + NADP+ (EC 1.1.1.201)
No genes
7α-hydroxy-3-oxo-5β-cholanate + NADPH + H+→isochenodeoxycholate + NADP+ (EC 1.1.1.393)
No genes
12-beta-hydroxysteroid dehydrogenase (in reverse):
12-dehydrodeoxycholate + NADPH + H+→12-epideoxycholate + NADP+ (EC 1.1.1.238)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information