MetaCyc Pathway: glyoxylate cycle in Escherichia coli BW25113
| Aconitate hydratase: citrate→cis-aconitate + H2O (EC 4.2.1.3) |
| b0118 (acnB) |
| b0771 (ybhJ) |
| b1276 (acnA) |
| Aconitate hydratase: cis-aconitate + H2O→D-threo-isocitrate (EC 4.2.1.3) |
| b0118 (acnB) |
| b0771 (ybhJ) |
| b1276 (acnA) |
| Isocitrate lyase: D-threo-isocitrate→glyoxylate + succinate (EC 4.1.3.1) |
| b4015 (aceA) |
| Malate synthase: glyoxylate + acetyl-CoA + H2O→(S)-malate + coenzyme A + H+ (EC 2.3.3.9) |
| b2976 (glcB) |
| b4014 (aceB) |
| Malate dehydrogenase: (S)-malate + NAD+→oxaloacetate + NADH + H+ (EC 1.1.1.37; 1.1.1.38) |
| b0801 (ybiC) |
| b1479 (sfcA) |
| b3236 (mdh) |
| Citrate (Si)-synthase: acetyl-CoA + oxaloacetate + H2O→citrate + coenzyme A + H+ (EC 2.3.3.1; 2.3.3.16; 2.3.3.3) |
| b0720 (gltA) |
Links:
- Pathway details at MetaCyc
- Fitness data for 10 genes
- All MetaCyc pathways for Escherichia coli BW25113
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information