MetaCyc Pathway: superpathway of glycol metabolism and degradation in Escherichia coli BW25113

Add experiment(s):


Lactaldehyde reductase:
ethylene glycol + NAD+→glycolaldehyde + NADH + H+ (EC 1.1.1.77)
b2799 (fucO)
Glycolaldehyde dehydrogenase:
glycolaldehyde + NAD+ + H2O→glycolate + NADH + 2 H+ (EC 1.2.1.21)
b1415 (aldA)
Glycolate dehydrogenase:
glycolate[in] + an electron-transfer quinone→glyoxylate[in] + an electron-transfer quinol (EC 1.1.99.14)
b1687 (ydiJ)
b2979 (glcD)
b4467 (glcF)
b4468 (glcE)
Tartronate-semialdehyde synthase:
2 glyoxylate + H+→(2R)-tartronate semialdehyde + CO2 (EC 4.1.1.47)
b0507 (gcl)
Malate synthase:
glyoxylate + acetyl-CoA + H2O→(S)-malate + coenzyme A + H+ (EC 2.3.3.9)
b2976 (glcB)
b4014 (aceB)
2-hydroxy-3-oxopropionate reductase (in reverse):
(2R)-tartronate semialdehyde + NAD(P)H + H+→D-glycerate + NAD(P)+ (EC 1.1.1.60)
b0509 (glxR)
b3125 (garR)
D-glycerate + ATP→2-phospho-D-glycerate + ADP + H+ (EC 2.7.1.165)
b0514 (glxK)
b3124 (garK)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information