MetaCyc Pathway: superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) in Erwinia tracheiphila SCR3

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Nucleoside-triphosphatase:
CTP + H2O→CDP + H+ + phosphate (EC 3.6.1.15; 3.6.1.5)
LU632_RS05450
Ribonucleoside-diphosphate reductase (in reverse):
UDP + a reduced NrdH glutaredoxin-like protein→dUDP + an oxidized NrdH glutaredoxin-like protein + H2O (EC 1.17.4.1)
LU632_RS08150 (nrdB)
LU632_RS08155 (nrdA)
LU632_RS16810 (nrdE)
LU632_RS16815 (nrdF)
CTP + formate + H+→dCTP + CO2 + H2O (EC 1.1.98.6)
LU632_RS20975 (nrdD)
formate + UTP + H+→dUTP + CO2 + H2O (EC 1.1.98.6)
LU632_RS20975 (nrdD)
Ribonucleoside-diphosphate reductase (in reverse):
UDP + a reduced thioredoxin→dUDP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
LU632_RS08150 (nrdB)
LU632_RS08155 (nrdA)
LU632_RS16805 (nrdI)
LU632_RS16810 (nrdE)
LU632_RS16815 (nrdF)
Ribonucleoside-diphosphate reductase (in reverse):
CDP + a reduced thioredoxin→dCDP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
LU632_RS08150 (nrdB)
LU632_RS08155 (nrdA)
LU632_RS16805 (nrdI)
LU632_RS16810 (nrdE)
LU632_RS16815 (nrdF)
Nucleoside-diphosphate kinase:
dUDP + ATP→dUTP + ADP (EC 2.7.4.6)
LU632_RS17820 (ndk)
Ribonucleoside-diphosphate reductase (in reverse):
CDP + a reduced NrdH glutaredoxin-like protein→dCDP + an oxidized NrdH glutaredoxin-like protein + H2O (EC 1.17.4.1)
LU632_RS08150 (nrdB)
LU632_RS08155 (nrdA)
LU632_RS16810 (nrdE)
LU632_RS16815 (nrdF)
Nucleoside-diphosphate kinase:
dCDP + ATP→dCTP + ADP (EC 2.7.4.6)
LU632_RS17820 (ndk)
LU632_RS18095 (adk)
dCTP deaminase:
dCTP + H+ + H2O→dUTP + ammonium (EC 3.5.4.13)
LU632_RS08745 (dcd)
dUTP diphosphatase:
dUTP + H2O→dUMP + diphosphate + H+ (EC 3.6.1.23; 3.6.1.9)
LU632_RS22005 (dut)
Thymidylate synthase:
dUMP + a 5,10-methylenetetrahydrofolate→dTMP + a 7,8-dihydrofolate (EC 2.1.1.45)
LU632_RS06120 (thyA)
T(2)-induced deoxynucleotide kinase:
dTMP + ATP→dTDP + ADP (EC 2.7.4.12; 2.7.4.13; 2.7.4.9)
LU632_RS14795 (tmk)
Nucleoside-diphosphate kinase:
dTDP + ATP→dTTP + ADP (EC 2.7.4.6)
LU632_RS17820 (ndk)
LU632_RS18095 (adk)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information