MetaCyc Pathway: lipid IVA biosynthesis (2,3-diamino-2,3-dideoxy-D-glucopyranose-containing) in Enterobacter asburiae PDN3

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UDP-2-acetamido-3-amino-2,3-dideoxy-α-D-glucopyranose + a (3R)-3-hydroxyhexadecanoyl-[acp]→UDP-2-acetamido-2,3-dideoxy-3-{[(3R)-3-hydroxyhexadecanoyl]amino}-α-D-glucopyranose + a soluble [acyl-carrier protein] (EC 2.3.1.305)
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UDP-2-acetamido-2,3-dideoxy-3-{[(3R)-3-hydroxyhexadecanoyl]amino}-α-D-glucopyranose + H2O→UDP-3-N-[(3R)-3-hydroxyhexanoyl]-α-3-amino-3-deoxy-D-glucosamine + acetate (EC 3.5.1.108)
EX28DRAFT_3691
UDP-3-N-[(3R)-3-hydroxyhexanoyl]-α-3-amino-3-deoxy-D-glucosamine + a (3R)-3-hydroxydodecanoyl-[acp]→UDP-2-N-[(3R)-3-hydroxydodecanoyl]-3-N-[(3R)-3-hydroxyhexanoyl]-α-3-amino-3-deoxy-D-glucosamine + a soluble [acyl-carrier protein] + H+ (EC 2.3.1.191)
EX28DRAFT_3767
UDP-2-N-[(3R)-3-hydroxydodecanoyl]-3-N-[(3R)-3-hydroxyhexanoyl]-α-3-amino-3-deoxy-D-glucosamine + H2O→lipid X (Brucella) + 2 H+ + UMP (EC 3.6.1.54)
EX28DRAFT_2456
Lipid-A-disaccharide synthase:
UDP-2-N-[(3R)-3-hydroxydodecanoyl]-3-N-[(3R)-3-hydroxyhexanoyl]-α-3-amino-3-deoxy-D-glucosamine + lipid X (Brucella)→dephospho-lipid IVA (Brucella) + H+ + UDP (EC 2.4.1.182)
EX28DRAFT_3770
Tetraacyldisaccharide 4'-kinase:
dephospho-lipid IVA (Brucella) + ATP→lipid IVA (Brucella) + ADP + H+ (EC 2.7.1.130)
EX28DRAFT_2021

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information