MetaCyc Pathway: colanic acid (Escherichia coli K12) biosynthesis in Enterobacter asburiae PDN3

Add experiment(s):


UDP-α-D-glucose + di-trans,octa-cis-undecaprenyl phosphate→α-D-Glc-PP-Und + UMP (EC 2.7.8.31)
EX28DRAFT_0508
α-D-Glc-PP-Und + GDP-β-L-fucose→α-L-Fuc-(1->3)-α-D-Glc-PP-Und + GDP + H+
EX28DRAFT_0505
α-L-Fuc-(1->3)-α-D-Glc-PP-Und + acetyl-CoA→2/3-O-Ac-α-L-Fuc-(1→3)-α-D-Glc-PP-Und + coenzyme A
EX28DRAFT_0501
GDP-β-L-fucose + 2/3-O-Ac-α-L-Fuc-(1→3)-α-D-Glc-PP-Und→α-L-Fuc-(1→4)-2/3-O-Ac-α-L-Fuc-(1→3)-α-D-Glc-PP-Und + GDP + H+
EX28DRAFT_0500
α-L-Fuc-(1→4)-2/3-O-Ac-α-L-Fuc-(1→3)-α-D-Glc-PP-Und + UDP-α-D-galactose→α-D-Gal-(1→3)-α-L-Fuc-(1→4)-2/3-O-Ac-α-L-Fuc-(1->3)-α-D-Glc-PP-Und + H+ + UDP
EX28DRAFT_0498
α-D-Gal-(1→3)-α-L-Fuc-(1→4)-2/3-O-Ac-α-L-Fuc-(1->3)-α-D-Glc-PP-Und + acetyl-CoA→2-O-Ac-α-D-Gal-(1→3)-α-L-Fuc-(1→4)-2/3-O-Ac-α-L-Fuc-(1→3)-α-D-Glc-PP-Und + coenzyme A
EX28DRAFT_0497
2-O-Ac-α-D-Gal-(1→3)-α-L-Fuc-(1→4)-2/3-O-Ac-α-L-Fuc-(1→3)-α-D-Glc-PP-Und + UDP-α-D-glucuronate→β-D-GlcA-(1→3)-2-O-Ac-α-D-Gal-(1→3)-α-L-Fuc-(1→4)-3-O-Ac-α-L-Fuc-(1→3)-α-D-Glc-PP-Und + H+ + UDP
EX28DRAFT_0496
UDP-α-D-galactose + β-D-GlcA-(1→3)-2-O-Ac-α-D-Gal-(1→3)-α-L-Fuc-(1→4)-3-O-Ac-α-L-Fuc-(1→3)-α-D-Glc-PP-Und→α-D-Gal-(1→4)-β-D-GlcA-(1→3)-2-O-Ac-α-D-Gal-(1→3)-α-L-Fuc-(1→4)-3-O-Ac-α-L-Fuc-(1→3)-α-D-Glc-PP-Und + H+ + UDP
No genes
α-D-Gal-(1→4)-β-D-GlcA-(1→3)-2-O-Ac-α-D-Gal-(1→3)-α-L-Fuc-(1→4)-3-O-Ac-α-L-Fuc-(1→3)-α-D-Glc-PP-Und + phosphoenolpyruvate→4,6-pyr-α-D-Gal-(1→4)-β-D-GlcA-(1→3)-2-O-Ac-α-D-Gal-(1→3)-α-L-Fuc-(1→4)-3-O-Ac-α-L-Fuc-(1→3)-α-D-Glc-PP-Und + phosphate
EX28DRAFT_0510
4,6-pyr-α-D-Gal-(1→4)-β-D-GlcA-(1→3)-2-O-Ac-α-D-Gal-(1→3)-α-L-Fuc-(1→4)-3-O-Ac-α-L-Fuc-(1→3)-α-D-Glc-PP-Und[in] + H+[out]→4,6-pyr-α-D-Gal-(1→4)-β-D-GlcA-(1→3)-2-O-Ac-α-D-Gal-(1→3)-α-L-Fuc-(1→4)-3-O-Ac-α-L-Fuc-(1→3)-α-D-Glc-PP-Und[out] + H+[in]
EX28DRAFT_0509
n 4,6-pyr-α-D-Gal-(1→4)-β-D-GlcA-(1→3)-2-O-Ac-α-D-Gal-(1→3)-α-L-Fuc-(1→4)-3-O-Ac-α-L-Fuc-(1→3)-α-D-Glc-PP-Und→colanic acid (E. coli K-12) attached to lipid anchor + n-1 H+ + n-1 di-trans,octa-cis-undecaprenyl diphosphate
EX28DRAFT_0499

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information