MetaCyc Pathway: superpathway of glycolysis and the Entner-Doudoroff pathway in Enterobacter asburiae PDN3

MetaCyc Pathway: superpathway of glycolysis and the Entner-Doudoroff pathway in Enterobacter asburiae PDN3

Glucose-6-phosphate dehydrogenase:
D-glucopyranose 6-phosphate + NADP⁺→6-phospho D-glucono-1,5-lactone + NADPH + H⁺ (EC 1.1.1.49)

D-glucopyranose_[out] + an [HPr protein]-N^π-phospho-L-histidine_[in]→D-glucopyranose 6-phosphate_[in] + an [HPr]-L-histidine_[in] (EC 2.7.1.199)

6-phosphogluconolactonase:
6-phospho D-glucono-1,5-lactone + H₂O→D-gluconate 6-phosphate + H⁺ (EC 3.1.1.31)

Glucose-6-phosphate isomerase:
α-D-glucose 6-phosphate→β-D-fructofuranose 6-phosphate (EC 5.3.1.9)

6-phosphofructokinase:
β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H⁺ (EC 2.7.1.11)

Phosphogluconate dehydratase:
D-gluconate 6-phosphate→2-dehydro-3-deoxy-D-gluconate 6-phosphate + H₂O (EC 4.2.1.12)

Fructose-bisphosphate aldolase:
β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)

Fructose-bisphosphatase:
β-D-fructofuranose 1,6-bisphosphate + H₂O→β-D-fructofuranose 6-phosphate + phosphate (EC 3.1.3.11)

2-dehydro-3-deoxy-phosphogluconate aldolase:
2-dehydro-3-deoxy-D-gluconate 6-phosphate→D-glyceraldehyde 3-phosphate + pyruvate (EC 4.1.2.14; 4.1.2.55)

Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD⁺ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H⁺ (EC 1.2.1.12)

Triose-phosphate isomerase (in reverse):
glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)

Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)

3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)

3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.11)

Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H₂O (EC 4.2.1.11)

Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H⁺→pyruvate + ATP (EC 2.7.1.40)

Pyruvate, water dikinase:
pyruvate + ATP + H₂O→phosphoenolpyruvate + AMP + 2 H⁺ + phosphate (EC 2.7.9.2)

Links:

Pathway details at MetaCyc
Fitness data for 35 genes
Select organism:
All MetaCyc pathways for Enterobacter asburiae PDN3

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information