MetaCyc Pathway: molybdopterin biosynthesis in Escherichia coli HS(pFamp)R (ATCC 700891)

Add experiment(s):


ATP + a small subunit of molybdopterin synthase + H+→a carboxy-adenylated [small subunit of molybdopterin synthase] + diphosphate (EC 2.7.7.80)
OHPLBJKB_02886
Cysteine desulfurase:
L-cysteine + a [molybdopterin synthase sulfurtransferase]-L-cysteine→a [molybdopterin synthase sulfurtransferase]-S-sulfanyl-L-cysteine + L-alanine (EC 2.8.1.7)
OHPLBJKB_00920
OHPLBJKB_00921
OHPLBJKB_01179
OHPLBJKB_02044
GTP + a reduced two electron carrier + S-adenosyl-L-methionine→(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + an oxidized electron carrier + 5'-deoxyadenosine + L-methionine + H+ (EC 4.1.99.22)
OHPLBJKB_02932
a carboxy-adenylated [small subunit of molybdopterin synthase] + a [molybdopterin synthase sulfurtransferase]-S-sulfanyl-L-cysteine + a reduced two electron carrier→a thiocarboxylated [small subunit of molybdopterin synthase] + AMP + an oxidized electron carrier + a [molybdopterin synthase sulfurtransferase]-L-cysteine + H+ (EC 2.8.1.11)
OHPLBJKB_01975
(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate→cyclic pyranopterin phosphate + diphosphate (EC 4.6.1.17)
OHPLBJKB_02930
cyclic pyranopterin phosphate + 2 a thiocarboxylated [small subunit of molybdopterin synthase] + H2O→molybdopterin + 2 a small subunit of molybdopterin synthase + 4 H+ (EC 2.8.1.12)
OHPLBJKB_02928
OHPLBJKB_02929

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information