MetaCyc Pathway: Entner-Doudoroff pathway III (semi-phosphorylative) in Escherichia coli HS(pFamp)R (ATCC 700891)

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Glucose 1-dehydrogenase (NADP(+)):
D-glucopyranose + NADP+→D-glucono-1,5-lactone + NADPH + H+ (EC 1.1.1.119; 1.1.1.360)
No genes
Gluconolactonase:
D-glucono-1,5-lactone + H2O→D-gluconate + H+ (spontaneous) (EC 3.1.1.17)
No genes
D-gluconate→2-dehydro-3-deoxy-D-gluconate + H2O (EC 4.2.1.140; 4.2.1.39)
No genes
2-dehydro-3-deoxy-D-gluconate + ATP→2-dehydro-3-deoxy-D-gluconate 6-phosphate + ADP + H+ (EC 2.7.1.178; 2.7.1.45)
OHPLBJKB_00176
2-dehydro-3-deoxy-phosphogluconate aldolase:
2-dehydro-3-deoxy-D-gluconate 6-phosphate→D-glyceraldehyde 3-phosphate + pyruvate (EC 4.1.2.14; 4.1.2.55)
OHPLBJKB_01879
D-glyceraldehyde 3-phosphate + NAD(P)+ + H2O→3-phospho-D-glycerate + NAD(P)H + 2 H+ (EC 1.2.1.90)
No genes
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
OHPLBJKB_00087
OHPLBJKB_02958
OHPLBJKB_03666
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
OHPLBJKB_00952
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
OHPLBJKB_01874
OHPLBJKB_02048

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information