MetaCyc Pathway: superpathway of purines degradation in plants in Escherichia coli HS(pFamp)R (ATCC 700891)

MetaCyc Pathway: superpathway of purines degradation in plants in Escherichia coli HS(pFamp)R (ATCC 700891)

Adenosine-phosphate deaminase:
AMP + H⁺ + H₂O→IMP + ammonium (EC 3.5.4.17; 3.5.4.6)

No genes

5'-nucleotidase:
GMP + H₂O→guanosine + phosphate (EC 3.1.3.5)

Guanosine deaminase:
guanosine + H⁺ + H₂O→xanthosine + ammonium (EC 3.5.4.15)

No genes

IMP dehydrogenase:
IMP + NAD⁺ + H₂O→XMP + NADH + H⁺ (EC 1.1.1.205)

5'-nucleotidase:
IMP + H₂O→inosine + phosphate (EC 3.1.3.5; 3.1.3.99)

Purine nucleosidase:
guanosine + H₂O→guanine + D-ribofuranose (EC 3.2.2.1)

Guanine deaminase:
guanine + H⁺ + H₂O→xanthine + ammonium (EC 3.5.4.3)

Inosine nucleosidase:
inosine + H₂O→hypoxanthine + D-ribofuranose (EC 3.2.2.2)

5'-nucleotidase:
XMP + H₂O→xanthosine + phosphate (EC 3.1.3.5)

Xanthine dehydrogenase:
hypoxanthine + NAD⁺ + H₂O→xanthine + NADH + H⁺ (EC 1.17.1.4)

Purine nucleosidase:
xanthosine + H₂O→xanthine + D-ribofuranose (EC 3.2.2.1)

Xanthine dehydrogenase:
xanthine + NAD⁺ + H₂O→urate + NADH + H⁺ (EC 1.17.1.4)

Urate oxidase:
urate + dioxygen + H₂O→(S)-5-hydroxyisourate + hydrogen peroxide (EC 1.7.3.3)

No genes

Hydroxyisourate hydrolase:
(S)-5-hydroxyisourate + H₂O→(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H⁺ (EC 3.5.2.17)

(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H⁺→(S)-(+)-allantoin + CO₂ (EC 4.1.1.97)

No genes

Allantoinase:
(S)-(+)-allantoin + H₂O→allantoate + H⁺ (EC 3.5.2.5)

Allantoicase:
allantoate + H₂O→(S)-ureidoglycolate + urea (EC 3.5.3.4)

No genes

Ureidoglycolate lyase:
(S)-ureidoglycolate→glyoxylate + urea (EC 4.3.2.3)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information