MetaCyc Pathway: glycine degradation in Escherichia coli ECRC99

glycine + NAD⁺ + a tetrahydrofolate→ammonium + a 5,10-methylenetetrahydrofolate + CO₂ + NADH (EC 1.4.1.27)

Glycine hydroxymethyltransferase (in reverse):
glycine + a 5,10-methylenetetrahydrofolate + H₂O→L-serine + a tetrahydrofolate (EC 2.1.2.1)

KEDOAH_06710 (glyA)

L-serine ammonia-lyase:
L-serine→ammonium + pyruvate (EC 4.3.1.17)

KEDOAH_01560 (sdaA)

KEDOAH_07955 (sdaB)

KEDOAH_09720 (tdcG)

KEDOAH_09745 (tdcB)

Links:

Pathway details at MetaCyc
Fitness data for 7 genes
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All MetaCyc pathways for Escherichia coli ECRC99

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information