MetaCyc Pathway: L-citrulline biosynthesis in Escherichia coli ECRC99

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Arginase:
L-arginine + H2O→L-ornithine + urea (EC 3.5.3.1)
No genes
Glutamate synthase (NADPH):
L-glutamine + H2O→L-glutamate + ammonia + H+ (EC 1.4.1.13; 1.4.1.14; 1.4.7.1; 2.6.1.85; 3.5.1.2; 3.5.1.38; 4.1.3.27; 4.3.2.10; 4.3.3.6; 6.3.4.2; 6.3.5.13; 6.3.5.2; 6.3.5.4; 6.3.5.5; 6.3.5.6; 6.3.5.7)
KEDOAH_01550 (pabB)
KEDOAH_06240 (aegA)
KEDOAH_06455 (guaA)
KEDOAH_07055 (ypjD)
KEDOAH_07860 (pyrG)
KEDOAH_08525 (ygfT)
KEDOAH_10265 (gltB)
KEDOAH_10270 (gltD)
KEDOAH_10920 (pabA)
KEDOAH_17210 (carA)
KEDOAH_17215 (carB)
KEDOAH_19900 (glsA)
KEDOAH_20790 (asnB)
KEDOAH_26090 (trpD)
KEDOAH_26095 (trpE)
KEDOAH_27315 (glsB)
L-proline[in] + an electron-transfer quinone→(S)-1-pyrroline-5-carboxylate[in] + an electron-transfer quinol + H+[in] (EC 1.5.5.2)
No genes
Glutamate 5-kinase:
L-glutamate + ATP→γ-L-glutamyl 5-phosphate + ADP (EC 2.7.2.11)
KEDOAH_18480 (proB)
(S)-1-pyrroline-5-carboxylate + H+ + H2O→L-glutamate 5-semialdehyde (spontaneous)
No genes
Glutamate-5-semialdehyde dehydrogenase (in reverse):
γ-L-glutamyl 5-phosphate + NADPH + H+→L-glutamate 5-semialdehyde + NADP+ + phosphate (EC 1.2.1.41)
KEDOAH_18485 (proA)
Ornithine aminotransferase (in reverse):
L-glutamate + L-glutamate 5-semialdehyde→L-ornithine + 2-oxoglutarate (EC 2.6.1.13)
No genes
Ornithine carbamoyltransferase:
L-ornithine + carbamoyl phosphate→L-citrulline + H+ + phosphate (EC 2.1.3.3)
KEDOAH_16320 (argF)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information