MetaCyc Pathway: superpathway of purine nucleotide salvage in Escherichia coli ECRC98

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Adenosine kinase:
adenosine + ATP→AMP + ADP + H+ (EC 2.7.1.20)
No genes
Purine-nucleoside phosphorylase:
adenosine + phosphate→adenine + α-D-ribose-1-phosphate (EC 2.4.2.1)
JDDGAC_12240 (ppnP)
JDDGAC_14810 (deoD)
JDDGAC_24920 (yfiH)
Adenylosuccinate synthase:
IMP + L-aspartate + GTP→adenylosuccinate + GDP + 2 H+ + phosphate (EC 6.3.4.4)
JDDGAC_15870 (purA)
IMP dehydrogenase:
IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)
JDDGAC_25435 (guaB)
Purine-nucleoside phosphorylase:
guanosine + phosphate→guanine + α-D-ribose-1-phosphate (EC 2.4.2.1; 2.4.2.15)
JDDGAC_12240 (ppnP)
JDDGAC_14810 (deoD)
Adenine phosphoribosyltransferase (in reverse):
adenine + 5-phospho-α-D-ribose 1-diphosphate→AMP + diphosphate (EC 2.4.2.7)
JDDGAC_11820 (apt)
Adenylosuccinate lyase:
adenylosuccinate→AMP + fumarate (EC 4.3.2.2)
JDDGAC_06630 (purB)
GMP synthase (glutamine-hydrolyzing):
XMP + ATP + L-glutamine + H2O→GMP + AMP + L-glutamate + diphosphate + 2 H+ (EC 6.3.5.2)
JDDGAC_25440 (guaA)
Hypoxanthine phosphoribosyltransferase (in reverse):
guanine + 5-phospho-α-D-ribose 1-diphosphate→GMP + diphosphate (EC 2.4.2.8)
JDDGAC_11820 (apt)
JDDGAC_13320 (gpt)
JDDGAC_14040 (hpt)
Adenylate kinase:
AMP + ATP→2 ADP (EC 2.7.4.3)
JDDGAC_11795 (adk)
Guanylate kinase:
GMP + ATP→GDP + ADP (EC 2.7.4.8)
JDDGAC_16320 (phnN)
JDDGAC_19190 (gmk)
Ribonucleoside-diphosphate reductase (in reverse):
ADP + a reduced thioredoxin→dADP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
JDDGAC_24490 (nrdF)
JDDGAC_24495 (nrdE)
JDDGAC_24500 (nrdI)
JDDGAC_27070 (nrdB)
JDDGAC_27080 (nrdA)
Nucleoside-diphosphate kinase:
GDP + ATP→GTP + ADP (EC 2.7.4.6)
JDDGAC_11795 (adk)
JDDGAC_25380 (ndk)
Nucleoside-diphosphate kinase:
dADP + ATP→ADP + dATP (EC 2.7.4.6)
JDDGAC_25380 (ndk)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information