MetaCyc Pathway: L-threonine degradation I in Escherichia coli ECRC98

MetaCyc Pathway: L-threonine degradation I in Escherichia coli ECRC98

Threonine ammonia-lyase:
L-threonine→(Z)-2-aminobutenoate + H₂O (EC 4.3.1.19)

JDDGAC_18255 (ilvA)

JDDGAC_22035 (tdcB)

1-aminocyclopropane-1-carboxylate deaminase:
(Z)-2-aminobutenoate→2-iminobutanoate (spontaneous) (EC 3.5.99.7; 4.3.1.19; 4.4.1.1; 4.4.1.11; 4.4.1.2)

JDDGAC_18255 (ilvA)

JDDGAC_22035 (tdcB)

2-iminobutanoate + H₂O→2-oxobutanoate + ammonium (spontaneous) (EC 3.5.99.10; 3.5.99.7; 4.3.1.19; 4.4.1.1; 4.4.1.11; 4.4.1.2)

JDDGAC_15515 (ridA)

JDDGAC_18255 (ilvA)

JDDGAC_22035 (tdcB)

JDDGAC_22055 (tdcF)

Formate C-acetyltransferase (in reverse):
2-oxobutanoate + coenzyme A→propanoyl-CoA + formate (EC 2.3.1.54)

JDDGAC_09120 (pflB)

JDDGAC_09780 (pflD)

JDDGAC_17245 (pflD)

JDDGAC_22050 (tdcE)

JDDGAC_25010 (grcA)

propanoyl-CoA + phosphate→propanoyl phosphate + coenzyme A (EC 2.3.1.222)

JDDGAC_26755 (pta)

Acetate kinase (in reverse):
propanoyl phosphate + ADP→propanoate + ATP (EC 2.7.2.1; 2.7.2.14; 2.7.2.15; 2.7.2.7)

JDDGAC_22045 (tdcD)

JDDGAC_26760 (ackA)

Links:

Pathway details at MetaCyc
Fitness data for 13 genes
Select organism:
All MetaCyc pathways for Escherichia coli ECRC98

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information