MetaCyc Pathway: glutathione-mediated detoxification I in Escherichia coli ECRC98

Add experiment(s):


Glutathione transferase:
RX + glutathione→a glutathione-S-conjugate + HX (EC 2.5.1.18)
JDDGAC_02100 (gstA)
JDDGAC_22100 (yqjG)
JDDGAC_26730 (yfcG)
JDDGAC_26735 (yfcF)
JDDGAC_27560 (maiA)
a glutathione-S-conjugate[in] + ATP[in] + H2O[in]→a glutathione-S-conjugate[out] + ADP[in] + H+[in] + phosphate[in] (EC 7.6.2.3)
No genes
a glutathione-S-conjugate + H2O→an (L-cysteinylglycine)-S-conjugate + L-glutamate (EC 3.4.19.13)
No genes
an (L-cysteinylglycine)-S-conjugate + H2O→an L-cysteine-S-conjugate + glycine (EC 3.4.13.23)
No genes
Cysteine-S-conjugate N-acetyltransferase:
an L-cysteine-S-conjugate + acetyl-CoA→a mercapturate + coenzyme A + H+ (EC 2.3.1.80)
No genes
Cysteine-S-conjugate beta-lyase:
an L-cysteine-S-conjugate→2-aminoprop-2-enoate + a thiol (EC 4.4.1.13)
No genes
Tryptophanase:
2-aminoprop-2-enoate→2-iminopropanoate (spontaneous) (EC 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
JDDGAC_00385 (dcyD)
JDDGAC_01125 (sdaA)
JDDGAC_18585 (tnaA)
JDDGAC_22060 (tdcG)
JDDGAC_23840 (sdaB)
JDDGAC_26410 (dsdA)
2-iminopropanoate + H2O→pyruvate + ammonium (spontaneous) (EC 3.5.99.10; 4.1.99.1; 4.1.99.2; 4.3.1.13; 4.3.1.17; 4.3.1.18; 4.3.3.8; 4.4.1.1; 4.4.1.13; 4.4.1.15; 4.4.1.25; 4.4.1.28; 4.4.1.35; 4.5.1.2)
JDDGAC_00385 (dcyD)
JDDGAC_01125 (sdaA)
JDDGAC_15515 (ridA)
JDDGAC_18585 (tnaA)
JDDGAC_22055 (tdcF)
JDDGAC_22060 (tdcG)
JDDGAC_23840 (sdaB)
JDDGAC_26410 (dsdA)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information