MetaCyc Pathway: superpathway of phospholipid biosynthesis III (E. coli) in Escherichia coli ECRC98

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Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) (in reverse):
glycerone phosphate + NAD(P)H + H+→sn-glycerol 3-phosphate + NAD(P)+ (EC 1.1.1.94)
JDDGAC_19380 (gpsA)
Glycerol-3-phosphate O-acyltransferase:
sn-glycerol 3-phosphate + an acyl-[acyl-carrier protein]→a 2-lysophosphatidate + a soluble [acyl-carrier protein] (EC 2.3.1.15)
JDDGAC_07250 (plsX)
JDDGAC_16700 (plsB)
JDDGAC_22330 (plsY)
Glycerol-3-phosphate O-acyltransferase:
sn-glycerol 3-phosphate + an acyl-CoA→a 2-lysophosphatidate + coenzyme A (EC 2.3.1.15)
JDDGAC_07250 (plsX)
JDDGAC_16700 (plsB)
JDDGAC_22330 (plsY)
1-acylglycerol-3-phosphate O-acyltransferase:
a 2-lysophosphatidate + an acyl-[acyl-carrier protein]→a phosphatidate + a soluble [acyl-carrier protein] (EC 2.3.1.51)
JDDGAC_17785 (yihG)
JDDGAC_22540 (plsC)
1-acylglycerol-3-phosphate O-acyltransferase:
a 2-lysophosphatidate + an acyl-CoA→a phosphatidate + coenzyme A (EC 2.3.1.51)
JDDGAC_17785 (yihG)
JDDGAC_22540 (plsC)
Phosphatidate cytidylyltransferase:
a phosphatidate + CTP + H+→a CDP-diacylglycerol + diphosphate (EC 2.7.7.41)
JDDGAC_04240 (ynbB)
JDDGAC_13775 (cdsA)
JDDGAC_13780 (uppS)
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase:
a CDP-diacylglycerol + sn-glycerol 3-phosphate→a phosphatidylglycerophosphate + CMP + H+ (EC 2.7.8.5)
JDDGAC_00420 (pgsA)
JDDGAC_04245 (ynbA)
CDP-diacylglycerol--serine O-phosphatidyltransferase:
a CDP-diacylglycerol + L-serine→a phosphatidylserine + CMP + H+ (EC 2.7.8.8)
JDDGAC_24975 (pssA)
JDDGAC_24980 (pssL)
Phosphatidylglycerophosphatase:
a phosphatidylglycerophosphate + H2O→a phosphatidylglycerol + phosphate (EC 3.1.3.27)
JDDGAC_05110 (pgpB)
JDDGAC_12090 (pgpA)
JDDGAC_25120 (yfhb)
Phosphatidylserine decarboxylase:
a phosphatidylserine + H+→a phosphatidylethanolamine + CO2 (EC 4.1.1.65)
JDDGAC_15960 (asd)
2 a phosphatidylglycerol→a cardiolipin + glycerol (EC 2.7.8.41)
JDDGAC_05915 (clsA)
JDDGAC_09965 (clsB)
a phosphatidylethanolamine + a phosphatidylglycerol→a cardiolipin + ethanolamine (EC 2.7.8.41)
JDDGAC_07470 (clsC)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information