MetaCyc Pathway: superpathway of N-acetylneuraminate degradation in Escherichia coli ECRC98

Add experiment(s):


N-acetyl-β-neuraminate→aceneuramate (EC 5.1.3.24)
JDDGAC_21495 (nanQ)
N-acetylneuraminate lyase:
aceneuramate→N-acetyl-D-mannosamine + pyruvate (EC 4.1.3.3)
JDDGAC_21475 (nanA)
N-acylmannosamine kinase:
N-acetyl-D-mannosamine + ATP→N-acetyl-D-mannosamine 6-phosphate + ADP + H+ (EC 2.7.1.60)
JDDGAC_21490 (nanK)
N-acylglucosamine-6-phosphate 2-epimerase:
N-acetyl-D-mannosamine 6-phosphate→N-acetyl-D-glucosamine 6-phosphate (EC 5.1.3.9)
JDDGAC_21485 (nanE)
N-acetylglucosamine-6-phosphate deacetylase:
N-acetyl-D-glucosamine 6-phosphate + H2O→D-glucosamine 6-phosphate + acetate (EC 3.5.1.25)
JDDGAC_10815 (nagA)
JDDGAC_21940 (nagA)
Glucosamine-6-phosphate deaminase:
D-glucosamine 6-phosphate + H2O→β-D-fructofuranose 6-phosphate + ammonium (EC 3.5.99.6)
JDDGAC_10810 (nagB)
6-phosphofructokinase:
β-D-fructofuranose 6-phosphate + ATP→β-D-fructofuranose 1,6-bisphosphate + ADP + H+ (EC 2.7.1.11)
JDDGAC_01610 (pfkB)
JDDGAC_17455 (pfkA)
Fructose-bisphosphate aldolase:
β-D-fructofuranose 1,6-bisphosphate→glycerone phosphate + D-glyceraldehyde 3-phosphate (EC 4.1.2.13)
JDDGAC_16365 (fba)
JDDGAC_20120 (fba)
JDDGAC_23025 (fbaA)
JDDGAC_28215 (fbaB)
Fructose-bisphosphatase:
β-D-fructofuranose 1,6-bisphosphate + H2O→β-D-fructofuranose 6-phosphate + phosphate (EC 3.1.3.11)
JDDGAC_10335 (ybhA)
JDDGAC_12280 (phoA)
JDDGAC_15585 (fbp)
JDDGAC_17405 (glpX)
JDDGAC_22975 (glpX)
Triose-phosphate isomerase (in reverse):
glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)
JDDGAC_17435 (tpiA)
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
JDDGAC_01305 (gapA)
JDDGAC_04185 (gap)
Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
JDDGAC_23020 (pgk)
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
JDDGAC_10390 (gpmA)
JDDGAC_14750
JDDGAC_19360 (gpmM)
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.11)
JDDGAC_10390 (gpmA)
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
JDDGAC_23940 (eno)
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
JDDGAC_00895 (pyk)
JDDGAC_01865 (pykF)
Pyruvate, water dikinase:
pyruvate + ATP + H2O→phosphoenolpyruvate + AMP + 2 H+ + phosphate (EC 2.7.9.2)
JDDGAC_01720 (ppsA)
Formate C-acetyltransferase (in reverse):
pyruvate + coenzyme A→acetyl-CoA + formate (EC 2.3.1.54)
JDDGAC_09120 (pflB)
JDDGAC_09325 (pflA)
JDDGAC_09770 (ybiY)
JDDGAC_09775
JDDGAC_09780 (pflD)
JDDGAC_17240 (pflC)
JDDGAC_17245 (pflD)
JDDGAC_22050 (tdcE)
JDDGAC_25010 (grcA)
Acetaldehyde dehydrogenase (acetylating) (in reverse):
acetyl-CoA + NADH + H+→acetaldehyde + coenzyme A + NAD+ (EC 1.2.1.10)
JDDGAC_05970 (adhE)
JDDGAC_12420 (mhpF)
JDDGAC_25990 (eutE)
Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)
JDDGAC_25975 (pta)
JDDGAC_26755 (pta)
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
JDDGAC_00925 (purT)
JDDGAC_22045 (tdcD)
JDDGAC_25960 (eutP)
JDDGAC_25965 (eutQ)
JDDGAC_26760 (ackA)
Alcohol dehydrogenase (in reverse):
acetaldehyde + NADH + H+→ethanol + NAD+ (EC 1.1.1.1)
JDDGAC_03855 (adhP)
JDDGAC_05970 (adhE)
JDDGAC_12395 (frmA)
JDDGAC_12580 (yahK)
JDDGAC_15410 (ahr)
JDDGAC_19485 (yiaY)
JDDGAC_21340 (acuI)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information