MetaCyc Pathway: superpathway of methylglyoxal degradation in Escherichia coli ECRC98

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Methylglyoxal reductase (NADPH-dependent) (in reverse):
methylglyoxal + NADPH + H+→(S)-lactaldehyde + NADP+ (EC 1.1.1.283)
JDDGAC_12775 (aRA1)
Lactoylglutathione lyase (in reverse):
methylglyoxal + glutathione→(R)-S-lactoylglutathione (EC 4.4.1.5)
JDDGAC_02020
Aldehyde reductase (in reverse):
methylglyoxal + NADPH + H+→hydroxyacetone + NADP+ (EC 1.1.1.21)
JDDGAC_01295 (yeaE)
JDDGAC_13600 (dkgB)
JDDGAC_22570 (dkgA)
JDDGAC_22580 (yqhD)
JDDGAC_22625 (gpr)
Hydroxyacylglutathione hydrolase:
(R)-S-lactoylglutathione + H2O→(R)-lactate + glutathione + H+ (EC 3.1.2.6)
JDDGAC_09000 (gloC)
JDDGAC_13575 (gloB)
JDDGAC_27470 (yeiG)
Lactaldehyde dehydrogenase:
(S)-lactaldehyde + NAD+ + H2O→(S)-lactate + NADH + 2 H+ (EC 1.2.1.22)
JDDGAC_04190 (aldA)
JDDGAC_19495 (aldB)
hydroxyacetone + NADH + H+→(S)-propane-1,2-diol + NAD+
JDDGAC_17270 (gldA)
(S)-lactate[in] + an electron-transfer quinone→pyruvate[in] + an electron-transfer quinol (EC 1.1.5.M6)
JDDGAC_19395 (lldD)
(R)-lactate[in] + an electron-transfer quinone→pyruvate[in] + an electron-transfer quinol (EC 1.1.5.12)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information