MetaCyc Pathway: superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation in Escherichia coli ECRC98

MetaCyc Pathway: superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation in Escherichia coli ECRC98

N-acetyl-β-neuraminate→aceneuramate (EC 5.1.3.24)

N-acetylneuraminate lyase:
aceneuramate→N-acetyl-D-mannosamine + pyruvate (EC 4.1.3.3)

N-acylmannosamine kinase:
N-acetyl-D-mannosamine + ATP→N-acetyl-D-mannosamine 6-phosphate + ADP + H⁺ (EC 2.7.1.60)

N-acylglucosamine-6-phosphate 2-epimerase:
N-acetyl-D-mannosamine 6-phosphate→N-acetyl-D-glucosamine 6-phosphate (EC 5.1.3.9)

JDDGAC_21485 (nanE)

N-acetylglucosamine-6-phosphate deacetylase:
N-acetyl-D-glucosamine 6-phosphate + H₂O→D-glucosamine 6-phosphate + acetate (EC 3.5.1.25)

JDDGAC_10815 (nagA)

JDDGAC_21940 (nagA)

Glucosamine-6-phosphate deaminase:
D-glucosamine 6-phosphate + H₂O→β-D-fructofuranose 6-phosphate + ammonium (EC 3.5.99.6)

JDDGAC_10810 (nagB)

Links:

Pathway details at MetaCyc
Fitness data for 7 genes
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All MetaCyc pathways for Escherichia coli ECRC98

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information