MetaCyc Pathway: superpathway of coenzyme A biosynthesis I (bacteria) in Escherichia coli ECRC62

Add experiment(s):


3-methyl-2-oxobutanoate hydroxymethyltransferase:
3-methyl-2-oxobutanoate + a 5,10-methylenetetrahydrofolate + H2O→2-dehydropantoate + a tetrahydrofolate (EC 2.1.2.11)
BNILDI_08925 (panB)
Aspartate 1-decarboxylase:
L-aspartate + H+→β-alanine + CO2 (EC 4.1.1.11)
BNILDI_08910 (panD)
2-dehydropantoate 2-reductase (in reverse):
2-dehydropantoate + NADPH + H+→(R)-pantoate + NADP+ (EC 1.1.1.169)
BNILDI_04765 (ilvC)
BNILDI_22760 (panE)
Pantoate--beta-alanine ligase:
β-alanine + (R)-pantoate + ATP→(R)-pantothenate + AMP + diphosphate + H+ (EC 6.3.2.1)
BNILDI_08920 (panC)
Pantothenate kinase:
(R)-pantothenate + ATP→(R)-4'-phosphopantothenate + ADP + H+ (EC 2.7.1.33)
BNILDI_05895 (coaA)
Phosphopantothenate--cysteine ligase:
(R)-4'-phosphopantothenate + CTP + L-cysteine→(R)-4'-phosphopantothenoyl-L-cysteine + CMP + diphosphate + H+ (EC 6.3.2.5)
BNILDI_04020 (coaBC)
Phosphopantothenoylcysteine decarboxylase:
(R)-4'-phosphopantothenoyl-L-cysteine + H+→4'-phosphopantetheine + CO2 (EC 4.1.1.36)
BNILDI_04020 (coaBC)
Pantetheine-phosphate adenylyltransferase:
4'-phosphopantetheine + ATP + H+→3'-dephospho-CoA + diphosphate (EC 2.7.7.3)
BNILDI_03995 (coaD)
Dephospho-CoA kinase:
3'-dephospho-CoA + ATP→coenzyme A + ADP + H+ (EC 2.7.1.24)
BNILDI_08705 (coaE)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information