MetaCyc Pathway: pyruvate fermentation to acetate and (<i>S</i>)-lactate I in Escherichia coli ECRC62

MetaCyc Pathway: pyruvate fermentation to acetate and (S)-lactate I in Escherichia coli ECRC62

L-lactate dehydrogenase (in reverse):
pyruvate + NADH + H⁺→(S)-lactate + NAD⁺ (EC 1.1.1.27)

BNILDI_00040 (ykgF)

BNILDI_00045 (ykgE)

pyruvate + coenzyme A + NAD⁺→acetyl-CoA + CO₂ + NADH (EC 1.2.1.104)

BNILDI_08765 (aceE)

BNILDI_08770 (aceF)

BNILDI_08775 (lpdA)

Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)

BNILDI_12520 (pta)

BNILDI_13330 (pta)

Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)

BNILDI_01335 (tdcD)

BNILDI_12505 (eutP)

BNILDI_12510 (eutQ)

BNILDI_13335 (ackA)

BNILDI_15655 (purT)

Links:

Pathway details at MetaCyc
Fitness data for 12 genes
Select organism:
All MetaCyc pathways for Escherichia coli ECRC62

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information