MetaCyc Pathway: heme b biosynthesis V (aerobic) in Escherichia coli ECRC102

Add experiment(s):


Uroporphyrinogen decarboxylase:
uroporphyrinogen-III + 4 H+→coproporphyrinogen III + 4 CO2 (EC 4.1.1.37)
NIAGMN_11110 (hemE)
Coproporphyrinogen oxidase:
coproporphyrinogen III + dioxygen + 2 H+→protoporphyrinogen IX + 2 CO2 + 2 H2O (EC 1.3.3.3)
NIAGMN_19865 (hemF)
protoporphyrinogen IX[in] + 3 a ubiquinone→protoporphyrin IX[in] + 3 a ubiquinol (EC 1.3.5.3)
NIAGMN_11980 (hemG)
protoporphyrin IX + Fe2+→protoheme + 2 H+ (EC 4.98.1.1)
NIAGMN_06195 (hemH)
NIAGMN_19890 (yfeX)
NIAGMN_23765 (efeB)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information