MetaCyc Pathway: (aminomethyl)phosphonate degradation in Escherichia coli ECRC101

α-D-ribose 1-(acetamidomethylphosphonate) 5-triphosphate + H₂O→α-D-ribose-1-(2-N-acetamidomethylphosphonate) 5-phosphate + diphosphate + H⁺ (EC 3.6.1.63)

MCAODC_03190 (phnM)

α-D-ribose-1-(2-N-acetamidomethylphosphonate) 5-phosphate + a reduced two electron carrier + S-adenosyl-L-methionine→5-phospho-α-D-ribose 1,2-cyclic phosphate + an oxidized electron carrier + 5'-deoxyadenosine + N-methylacetamide + L-methionine + H⁺ (EC 4.7.1.1)

MCAODC_03175 (phnJ)

5-phospho-α-D-ribose 1,2-cyclic phosphate + H₂O→α-D-ribose 1,5-bisphosphate + H⁺ (EC 3.1.4.55)

MCAODC_03205 (phnP)

Ribose 1,5-bisphosphate phosphokinase:
α-D-ribose 1,5-bisphosphate + ATP→5-phospho-α-D-ribose 1-diphosphate + ADP (EC 2.7.4.23)

MCAODC_03195 (phnN)

Adenine phosphoribosyltransferase (in reverse):
5-phospho-α-D-ribose 1-diphosphate + adenine→diphosphate + AMP (EC 2.4.2.7)

MCAODC_27395 (apt)

Inorganic diphosphatase:
diphosphate + H₂O→2 phosphate + H⁺ (EC 3.6.1.1)

MCAODC_02490 (ppa)

MCAODC_27850 (phoA)

Links:

Pathway details at MetaCyc
Fitness data for 9 genes
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All MetaCyc pathways for Escherichia coli ECRC101

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information