MetaCyc Pathway: superpathway of L-phenylalanine biosynthesis in Escherichia coli ECRC101

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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
MCAODC_11745 (aroF)
MCAODC_18275 (aroH)
MCAODC_25960 (aroG)
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
MCAODC_07645 (aroB)
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
MCAODC_10800 (eno)
MCAODC_18215 (aroD)
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
MCAODC_08085 (aroE)
MCAODC_18210 (ydiB)
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
MCAODC_07640 (aroK)
MCAODC_27825 (aroL)
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
MCAODC_24875 (aroA)
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
MCAODC_13655 (aroC)
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
MCAODC_11750 (tyrA)
MCAODC_11755 (pheA)
Prephenate dehydratase:
prephenate + H+→3-phenyl-2-oxopropanoate + CO2 + H2O (EC 4.2.1.51)
MCAODC_11755 (pheA)
Aspartate transaminase (in reverse):
3-phenyl-2-oxopropanoate + L-glutamate→L-phenylalanine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
MCAODC_01965 (yjiR)
MCAODC_03430 (tyrB)
MCAODC_05150 (ilvE)
MCAODC_11375 (aRO8)
MCAODC_16360 (ydcR)
MCAODC_20430 (hisC)
MCAODC_24775 (aspC)

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information